RGD Reference Report - A rat mutation producing demyelination (dmy) maps to chromosome 17. - Rat Genome Database

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A rat mutation producing demyelination (dmy) maps to chromosome 17.

Authors: Kuramoto, T  Sotelo, C  Yokoi, N  Serikawa, T  Gonalons Sintes, E  Canto Martorell, J  Guenet, JL 
Citation: Kuramoto T, etal., Mamm Genome 1996 Dec;7(12):890-4.
RGD ID: 1300413
Pubmed: PMID:8995759   (View Abstract at PubMed)

A recessive mutation exhibiting severe myelin breakdown, mainly at the level of the lumbar segments of the spinal cord and without any associated inflammation, was discovered in a partially inbred rat colony. Analysis of the segregation patterns of a set of polymorphic microsatellite markers in two inter-strain crosses allowed the mapping of this autosomal recessive mutation to rat Chromosome (Chr) 17, very close to the prolactin (Prl) locus, in a region homologous to human Chr 6p21.2-22.3 and mouse Chr 13. The pathology of the demyelination process and the chromosomal localization indicate that this mutation has no known equivalent in either mouse or human.

Objects referenced in this article
Strain DMY/Kyo demyelination rat Rattus norvegicus
Strain STOCK.dmyTg(CMV-Mrs2)Kyo null Rattus norvegicus

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