RGD Reference Report - Three dynamin-encoding genes are differentially expressed in developing rat brain. - Rat Genome Database

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Three dynamin-encoding genes are differentially expressed in developing rat brain.

Authors: Cook, T  Mesa, K  Urrutia, R 
Citation: Cook T, etal., J Neurochem 1996 Sep;67(3):927-31.
RGD ID: 1299609
Pubmed: PMID:8752097   (View Abstract at PubMed)

Dynamin proteins are members of a recently described family of GTPases involved in receptor-mediated processes. To date, three different dynamin-encoding genes have been identified in mammalian tissues. Dynamin I is expressed only in neurons, whereas dynamin II is ubiquitously expressed. A third isoform, dynamin III, was originally isolated from a rat testis cDNA library and shown to be testis-specific. However, here we report the cloning and characterization of dynamin III from brain and lung, demonstrating a more extended pattern of expression for this isoform. In addition, we have investigated the temporal pattern of expression of these three genes during brain development. We find that both dynamin I and dynamin III mRNA levels are up-regulated during embryogenesis, whereas dynamin II mRNA levels remain unchanged. From these results, we conclude that dynamin III is not a testis-specific isoform and, furthermore, that rat brain expresses three different dynamin-encoding genes that are differentially regulated during development. Therefore, this large isoform diversity of dynamin proteins in brain predicts a significant complexity in the understanding of dynamin-based processes in this tissue.

Objects referenced in this article
Gene Dnm3 dynamin 3 Rattus norvegicus

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