RGD Reference Report - Full sequence of neurocalcin, a novel calcium-binding protein abundant in central nervous system. - Rat Genome Database

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Full sequence of neurocalcin, a novel calcium-binding protein abundant in central nervous system.

Authors: Okazaki, K  Watanabe, M  Ando, Y  Hagiwara, M  Terasawa, M  Hidaka, H 
Citation: Okazaki K, etal., Biochem Biophys Res Commun 1992 May 29;185(1):147-53.
RGD ID: 1299474
Pubmed: PMID:1599450   (View Abstract at PubMed)

We determined the cDNA sequence for neurocalcin, a novel calcium-binding protein in bovine brain. This clone (pCalN) has 582 nucleotides in the open reading frame including the termination codon TGA, 11 nucleotides of the 5' leader and 1251 nucleotides of the 3' noncoding region. The deduced amino acid sequence revealed that neurocalcin is composed of 193 amino acids, has a molecular mass of 22,284 daltons, and contains three putative calcium-binding sites (EF-hand motifs). By Northern blot analysis, 3.8kbp mRNA was detected in brain. The deduced amino acid sequence had a strong homology to visinin (46.5%) and recoverin (51.6%) in retina, suggesting that neurocalcin may play a visinin- or recoverin-like role in brain.

Objects referenced in this article
Gene Hpcal4 hippocalcin-like 4 Rattus norvegicus

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