RGD Reference Report - The ARF1 GTPase-activating protein: zinc finger motif and Golgi complex localization. - Rat Genome Database

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The ARF1 GTPase-activating protein: zinc finger motif and Golgi complex localization.

Authors: Cukierman, E  Huber, I  Rotman, M  Cassel, D 
Citation: Cukierman E, etal., Science 1995 Dec 22;270(5244):1999-2002.
RGD ID: 1299452
Pubmed: PMID:8533093   (View Abstract at PubMed)

Hydrolysis of guanosine triphosphate (GTP) by the small guanosine triphosphatase (GTPase) adenosine diphosphate ribosylation factor-1 (ARF1) depends on a GTPase-activating protein (GAP). A complementary DNA encoding the ARF1 GAP was cloned from rat liver and predicts a protein with a zinc finger motif near the amino terminus. The GAP function required an intact zinc finger and additional amino-terminal residues. The ARF1 GAP was localized to the Golgi complex and was redistributed into a cytosolic pattern when cells were treated with brefeldin A, a drug that prevents ARF1-dependent association of coat proteins with the Golgi. Thus, the GAP is likely to be recruited to the Golgi by an ARF1-dependent mechanism.

Objects referenced in this article
Gene Arfgap1 ADP-ribosylation factor GTPase activating protein 1 Rattus norvegicus

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