RGD Reference Report - Cloning and sequence of the cDNA coding for rat type II Fc gamma receptor of mast cells. - Rat Genome Database

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Cloning and sequence of the cDNA coding for rat type II Fc gamma receptor of mast cells.

Authors: Bocek, P  Pecht, I 
Citation: Bocek P and Pecht I, FEBS Lett 1993 Sep 27;331(1-2):86-90.
RGD ID: 1299357
Pubmed: PMID:8405417   (View Abstract at PubMed)

A clone encoding the rat type II Fc gamma receptor was isolated from a cDNA library of the rat mucosal mast cell line RBL-2H3 and its sequence determined. The predicted amino acid sequence is highly homologous with the mouse type II as well as rat type III Fc gamma receptors. The site of alternative splicing which generates the mouse Fc gamma Rb2 isoform is completely conserved. Hence we consider the new sequence to encode a rat Fc gamma RII b2 isoform. In further analogy to the mouse receptor, no consensus motif known to be involved in accessory chain association was observed in the transmembranal domain. The importance of the identification of this receptor for investigation of the immunological stimulation of mast cells is discussed.

Molecular Pathway Annotations    Click to see Annotation Detail View

RGD Manual Annotations

TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
adaptive immune response pathway  ISS 1299357 RGD 
Objects Annotated

Genes (Rattus norvegicus)
Fcgr2b  (Fc gamma receptor 2B)


Additional Information