RGD Reference Report - Expression of mitochondrial tricarboxylate carrier TCC mRNA and protein in the rat brain. - Rat Genome Database

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Expression of mitochondrial tricarboxylate carrier TCC mRNA and protein in the rat brain.

Authors: Miyake, S  Yamashita, T  Taniguchi, M  Tamatani, M  Sato, K  Kawai, Y  Senba, E  Mitsuda, N  Hori, O  Yamaguchi, A  Tohyama, M 
Citation: Miyake S, etal., Brain Res Mol Brain Res 2002 Apr 30;100(1-2):67-73.
RGD ID: 1299286
Pubmed: PMID:12008022   (View Abstract at PubMed)

The tricarboxylate carrier protein catalyzes an electroneutral exchange across the mitochondrial inner membrane of tricarboxylate, dicarboxylate or phosphoenolpyruvate. We examined expression and localization of mitochondrial tricarboxylate carrier TCC mRNA and protein in the rat brain. TCC mRNA was ubiquitously expressed in all rat tissues examined and was abundant in brain, liver and kidney. TCC protein as well as mRNA was widely expressed in brain, and the protein expression was strong in neuronal cells in the hippocampus, the olfactory bulb, the corpus mamillare and the cerebellum. Our results suggest that this tricarboxylate carrier protein may contribute to biosynthesis and bioenergetics in neuronal cells in brain.

Gene Ontology Annotations    Click to see Annotation Detail View

Molecular Function
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
tricarboxylate secondary active transmembrane transporter activity  TAS 1299286 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Sfxn3  (sideroflexin 3)


Additional Information