RGD Reference Report - Placental lactogen-I variant utilizes the prolactin receptor signaling pathway. - Rat Genome Database

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Placental lactogen-I variant utilizes the prolactin receptor signaling pathway.

Authors: Cohick, CB  Dai, G  Xu, L  Deb, S  Kamei, T  Levan, G  Szpirer, C  Szpirer, J  Kwok, SC  Soares, MJ 
Citation: Cohick CB, etal., Mol Cell Endocrinol 1996 Jan 15;116(1):49-58.
RGD ID: 1298822
Pubmed: PMID:8822264   (View Abstract at PubMed)

Placenta lactogen-I variant (PL-Iv) is a member of a family of proteins expressed by the rat placenta with characteristics similar to prolactin (PRL). In this report, we present the molecular cloning, chromosomal localization, and heterologous expression of PL-Iv. Nucleotide sequence analysis of the PL-Iv cDNA clone predicted a precursor protein of 223 amino acids, including a 28-amino acid signal sequence. The PL-Iv gene was localized to chromosome 17 of the rat genome, which also carries other members of the PRL gene family. PL-Iv heterologously expressed in Chinese Hamster ovary (CHO) cells exhibited similar immunoreactive and electrophoretic characteristics with PL-Iv produced by the rat placenta. N-terminal sequencing verified the identity and purity of the recombinant PL-Iv species and the site of cleavage of the signal peptide from the mature secreted PL-Iv species. Recombinant PL-Iv was shown to bind to ovarian and liver PRL receptors, stimulate the proliferation of Nb2 lymphoma cells, and activate Jak2. Each of these actions is consistent with PL-Iv utilizing the PRL receptor signal transduction pathway.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Prl3d4Ratactivation of Janus kinase activity  IMP  RGD 
Prl3d4Ratpositive regulation of cell population proliferation  IMP  RGD 

Molecular Function

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Prl3d4Ratprolactin receptor binding  IMP  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Prl3d4  (prolactin family 3, subfamily D, member 4)


Additional Information