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Melatonin synthesis: analysis of the more than 150-fold nocturnal increase in serotonin N-acetyltransferase messenger ribonucleic acid in the rat pineal gland.

Authors: Roseboom, PH  Coon, SL  Baler, R  McCune, SK  Weller, JL  Klein, DC 
Citation: Roseboom PH, etal., Endocrinology 1996 Jul;137(7):3033-45.
Pubmed: (View Article at PubMed) PMID:8770929
DOI: Full-text: DOI:10.1210/endo.137.7.8770929

In vertebrates, the circadian rhythm in the activity of serotonin N-acetyltransferase [arylalkylamine N-acetyltransferase (AA-NAT); EC] drives the daily rhythm in circulating melatonin. We have discovered that expression of the AA-NAT gene in the rat pineal gland is essentially turned off during the day and turned on at night, resulting in a more than 150-fold rhythm. Expression is regulated by a photoneural system that acts through an adrenergic-cAMP mechanism in pinealocytes, probably involving cAMP response element-binding protein phosphorylation. Turning off AA-NAT expression appears to involve de novo synthesis of a protein that attenuates transcription. A approximately 10-fold night/day rhythm in AA-NAT messenger RNA occurs in the retina, and AA-NAT messenger RNA is also detected at low levels in the brain.


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RGD Object Information
RGD ID: 1298540
Created: 2004-06-01
Species: All species
Last Modified: 2004-06-01
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.