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Nucleotide and calcium-induced conformational changes in histone H1.

Authors: Tarkka, T  Oikarinen, J  Grundström, T 
Citation: Tarkka T, etal., FEBS Lett. 1997 Apr 7;406(1-2):56-60.
Pubmed: (View Article at PubMed) PMID:9109385

The principal constituents of chromatin, histone H1 (H1) and the nucleosome have essential roles in regulation of eukaryotic gene expression. However, mechanisms for the H1-dependent inactivation and for the ATP-dependent chromatin remodeling upon activation are largely unelucidated. Using circular dichroism (CD) analysis we show that ATP and other nucleotides and Ca2+ induce structural changes in H1. ATP and Ca2+ also induce changes when H1 is interacting with DNA, and the changes in H1 are accompanied by alterations in its DNA interaction. These results suggest that nucleotide and Ca2+ binding may be important for H1-mediated chromatin changes.


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RGD Object Information
RGD ID: 12793017
Created: 2017-03-18
Species: All species
Last Modified: 2017-03-18
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.