RGD Reference Report - Induction of atypical EAE mediated by transgenic production of IL-6 in astrocytes in the absence of systemic IL-6. - Rat Genome Database

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Induction of atypical EAE mediated by transgenic production of IL-6 in astrocytes in the absence of systemic IL-6.

Authors: Giralt, Mercedes  Ramos, Raquel  Quintana, Albert  Ferrer, Beatriz  Erta, Maria  Castro-Freire, Marco  Comes, Gemma  Sanz, Elisenda  Unzeta, Mercedes  Pifarré, Paula  García, Agustina  Campbell, Iain L  Hidalgo, Juan 
Citation: Giralt M, etal., Glia. 2013 Apr;61(4):587-600. doi: 10.1002/glia.22457. Epub 2013 Jan 16.
RGD ID: 12791289
Pubmed: PMID:23322593   (View Abstract at PubMed)
DOI: DOI:10.1002/glia.22457   (Journal Full-text)

Interleukin (IL)-6 is crucial for the induction of many murine models of autoimmunity including experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis. While IL-6-deficient mice (IL-6 KO) are resistant to EAE, we showed previously that in transgenic mice with astrocyte-targeted production of IL-6-restricted to the cerebellum (GFAP-IL6), EAE induced with MOG(35-55) was redirected away from the spinal cord to the cerebellum. To further establish the importance of IL-6 produced in the central nervous system, we have generated mice producing IL-6 essentially only in the brain by crossing the GFAP-IL6 mice with IL-6 KO mice. Interestingly, GFAP-IL6-IL-6 KO mice showed a milder but almost identical phenotype as the GFAP-IL6 mice, which correlated with a lower load of inflammatory cells and decreased microglial reactivity. These results indicate that not only is cerebellar IL-6 production and eventual leakage into the peripheral compartment the dominating factor controlling this type of EAE but that it can also facilitate induction of autoimmunity in the absence of normal systemic IL-6 production.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
IL6HumanExperimental Autoimmune Encephalomyelitis  ISOIl6 (Mus musculus) RGD 
Il6RatExperimental Autoimmune Encephalomyelitis  ISOIl6 (Mus musculus) RGD 
Il6MouseExperimental Autoimmune Encephalomyelitis  IMP  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Il6  (interleukin 6)

Genes (Mus musculus)
Il6  (interleukin 6)

Genes (Homo sapiens)
IL6  (interleukin 6)


Additional Information