RGD Reference Report - A novel kinesin-like protein, KIF1Bbeta3 is involved in the movement of lysosomes to the cell periphery in non-neuronal cells. - Rat Genome Database

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A novel kinesin-like protein, KIF1Bbeta3 is involved in the movement of lysosomes to the cell periphery in non-neuronal cells.

Authors: Matsushita, Masafumi  Tanaka, Shingo  Nakamura, Norihiro  Inoue, Hiroki  Kanazawa, Hiroshi 
Citation: Matsushita M, etal., Traffic. 2004 Mar;5(3):140-51.
RGD ID: 12738405
Pubmed: PMID:15086790   (View Abstract at PubMed)
DOI: DOI:10.1111/j.1600-0854.2003.00165.x   (Journal Full-text)

The kinesin superfamily protein, KIF1Bbeta, a splice variant of KIF1B, is involved in the transport of synaptic vesicles in neuronal cells, and is also expressed in various non-neuronal tissues. To elucidate the functions of KIF1Bbeta in non-neuronal cells, we analyzed the intracellular localization of KIF1Bbeta and characterized its isoform expression profile. In COS-7 cells, KIF1B colocalized with lysosomal markers and expression of a mutant form of KIF1Bbeta, lacking the motor domain, impaired the intracellular distribution of lysosomes. A novel isoform of the kinesin-like protein, KIF1Bbeta3, was identified in rat and simian kidney. It lacks the 5th exon of the KIF1Bbeta-specific tail region. Overexpression of KIF1Bbeta3 induced the translocation of lysosomes to the cell periphery. However, overexpression of KIF1Bbeta3-Q98L, which harbors a pathogenic mutation associated with a familial neuropathy, Charcot-Marie-Tooth disease type 2 A, resulted in the abnormal perinuclear clustering of lysosomes. These results indicate that KIF1Bbeta3 is involved in the translocation of lysosomes from perinuclear regions to the cell periphery.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
lysosome localization  IMP 12738405 RGD 
organelle transport along microtubule involved_inIMP 12738405PMID:15086790UniProt 
protein localization to cell periphery  IMP 12738405 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Kif1b  (kinesin family member 1B)


Additional Information