RGD Reference Report - Serum soluble CD163 levels in patients with influenza-associated encephalopathy. - Rat Genome Database

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Serum soluble CD163 levels in patients with influenza-associated encephalopathy.

Authors: Hasegawa, Shunji  Matsushige, Takeshi  Inoue, Hirofumi  Takahara, Midori  Kajimoto, Madoka  Momonaka, Hiroshi  Ishida, Chiemi  Tanaka, Saya  Morishima, Tsuneo  Ichiyama, Takashi 
Citation: Hasegawa S, etal., Brain Dev. 2013 Aug;35(7):626-9. doi: 10.1016/j.braindev.2012.10.005. Epub 2012 Nov 11.
RGD ID: 127345135
Pubmed: PMID:23149357   (View Abstract at PubMed)
DOI: DOI:10.1016/j.braindev.2012.10.005   (Journal Full-text)


BACKGROUND: Influenza-associated encephalopathy (IE) is a serious complication during influenza viral infection. Common clinical symptoms of IE include seizures and progressive coma with high-grade fever. We previously reported that hypercytokinemia and monocyte/macrophage activation may play an important role in the pathogenesis of IE. CD163 is a scavenger receptor for hemoglobin-haptoglobin complexes and is expressed by monocytes/macrophages. Proteolytic cleavage of monocyte-bound CD163 by matrix metalloproteinases releases soluble CD163 (sCD163). However, there have been no reports regarding serum sCD163 levels in IE patients.
METHODS: We measured serum levels of sCD163 as a marker of monocyte/macrophage activation in IE patients with poor outcomes, those without neurological sequelae, influenza patients without IE, and control subjects.
RESULTS: Serum sCD163 levels were significantly higher in IE patients with poor outcomes than in those without neurological sequelae. In particular, sCD163 levels in cases of death were significantly higher than those in other cases.
CONCLUSIONS: Our results suggest that monocyte/macrophage activation is related to the pathogenesis of severe IE.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
CD163HumanENCEPHALOPATHY, ACUTE, INFECTION-INDUCED, 9 exacerbatesIEP associated with Human Influenza and protein:increased expression:blood serum (human)RGD 
Cd163RatENCEPHALOPATHY, ACUTE, INFECTION-INDUCED, 9 exacerbatesISOCD163 (Homo sapiens)associated with Human Influenza and protein:increased expression:blood serum (human)RGD 
Cd163MouseENCEPHALOPATHY, ACUTE, INFECTION-INDUCED, 9 exacerbatesISOCD163 (Homo sapiens)associated with Human Influenza and protein:increased expression:blood serum (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Cd163  (CD163 molecule)

Genes (Mus musculus)
Cd163  (CD163 antigen)

Genes (Homo sapiens)
CD163  (CD163 molecule)


Additional Information