RGD Reference Report - Decay-accelerating factor (CD55) promotes CD1d expression and Vgamma4+ T-cell activation in coxsackievirus B3-induced myocarditis. - Rat Genome Database

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Decay-accelerating factor (CD55) promotes CD1d expression and Vgamma4+ T-cell activation in coxsackievirus B3-induced myocarditis.

Authors: Huber, Sally  Song, Wen-Chao  Sartini, Danielle 
Citation: Huber S, etal., Viral Immunol. 2006 Summer;19(2):156-66. doi: 10.1089/vim.2006.19.156.
RGD ID: 127345109
Pubmed: (View Article at PubMed) PMID:16817758
DOI: Full-text: DOI:10.1089/vim.2006.19.156

BALB/c mice infected with the H3 variant of Coxsackievirus B3 (CVB3) develop severe myocarditis which is initiated by up-regulation of CD1d during infection and CD1d-dependent activation of T cells expressing the Vgamma4 T cell receptor. Previous studies have shown that a mutant variant of the H3 virus which shows reduced binding avidity to one of the known CVB3 virus receptors, decay accelerating factor (DAF), fails to up-regulate CD1d or activate Vgamma4+ cells. To determine if DAF has a role in CD1d expression during infection or Vgamma4+ cell activation, BALB/c and BALB/c DAF-/- mice were infected with CVB3. Infected DAF-/- mice show modest increases in CD1d expression compared to infected wild-type BALB/c mice; and although total numbers of Vgamma4+ cells in the spleen are the same as in BALB/c mice, few Vgamma4+ IFNgamma+ cells are detected in infected DAF-/- animals. Vgamma4+ cell depletion protects infected BALB/c mice from myocarditis but does not protect infected DAF-/- animals, indicating that Vgamma4+ cells are not important to disease in these animals. Anti-CD8 depletion of CD8+ T cells protects infected BALB/c mice but aggravates disease in infected DAF-/- animals, indicating that the immunopathogenicity of viral myocarditis differs in the absence of the DAF virus receptor.

Annotation

Disease Annotations    

Objects Annotated

Genes (Rattus norvegicus)
Cd1d1  (CD1d1 molecule)

Genes (Mus musculus)
Cd1d1  (CD1d1 antigen)

Genes (Homo sapiens)
CD1D  (CD1d molecule)


Additional Information