RGD Reference Report - Differential requirement for CD18 in T-helper effector homing. - Rat Genome Database

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Differential requirement for CD18 in T-helper effector homing.

Authors: Lee, Seung-Hyo  Prince, Joseph E  Rais, Muhammad  Kheradmand, Farrah  Shardonofsky, Felix  Lu, Huifang  Beaudet, Arthur L  Smith, C Wayne  Soong, Lynn  Corry, David B 
Citation: Lee SH, etal., Nat Med. 2003 Oct;9(10):1281-6. doi: 10.1038/nm932. Epub 2003 Sep 14.
RGD ID: 127285813
Pubmed: PMID:14502280   (View Abstract at PubMed)
DOI: DOI:10.1038/nm932   (Journal Full-text)

To understand the integrin requirements of T-helper (T(H)) effector subsets, we investigated the contribution of CD18 (beta(2) integrin) to T(H)1 and T(H)2 function in vitro and in relevant disease models. CD18-deficient (Itgb2(-/-)) T cells showed largely normal in vitro function. Compared with wild-type mice, Itgb2(-/-) mice were better able to resolve Leishmania major infection and generated a superior T(H)1 immune response, as assessed from draining lymph nodes. In contrast, T(H)2-dependent allergic lung disease was markedly impaired in mutant mice. In both models, development of T(H)1 and T(H)2 cells in spleens was normal, but accumulation of T(H)2 (not T(H)1) cells at inflammatory sites was reduced. Thus, CD18 is selectively required for T(H)2, but not T(H)1, homing and has a minimal influence on T-effector development. These findings suggest a new integrin-based therapeutic approach in which the outcomes of diverse diseases may be favorably influenced by altering the homing of T(H)2 cells.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
ITGB2Humanleishmaniasis amelioratesISOItgb2 (Mus musculus) RGD 
Itgb2Ratleishmaniasis amelioratesISOItgb2 (Mus musculus) RGD 
Itgb2Mouseleishmaniasis amelioratesIMP  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Itgb2  (integrin subunit beta 2)

Genes (Mus musculus)
Itgb2  (integrin beta 2)

Genes (Homo sapiens)
ITGB2  (integrin subunit beta 2)


Additional Information