RGD Reference Report - Vitamin D suppresses macrophage infiltration by down-regulation of TREM-1 in diabetic nephropathy rats. - Rat Genome Database

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Vitamin D suppresses macrophage infiltration by down-regulation of TREM-1 in diabetic nephropathy rats.

Authors: Zhao, Yu  Guo, Yinfeng  Jiang, Yuteng  Zhu, Xiaodong  Zhang, Xiaoliang 
Citation: Zhao Y, etal., Mol Cell Endocrinol. 2018 Sep 15;473:44-52. doi: 10.1016/j.mce.2018.01.001. Epub 2018 Jan 10.
RGD ID: 127284861
Pubmed: (View Article at PubMed) PMID:29331667
DOI: Full-text: DOI:10.1016/j.mce.2018.01.001

This study intends to investigate the effect of active vitamin D (VD) on the expression of triggering receptor expressed on myeloid cells-1 (TREM-1) in the renal tissues of diabetic nephropathy (DN) rats and to explore the impact of TREM-1 on macrophage adhesion and migration. We find that the expressions of TREM-1 and CD68 protein are higher in DN rats compared with rats in the normal control group and that these changes are decreased in the DN + VD group. In vitro, the capacity for macrophage adhesion and migration and the expression of TREM-1 are increased under high-glucose conditions, but VD inhibits this progress. TREM-1 siRNA decreases high-glucose-induced macrophage adhesion and migration, whereas over-expression of TREM-1 inhibits its action. However, VD cannot suppress high glucose-induced TREM-1 expression and macrophage adhesion and migration when TREM-1 is over-expressed. These results demonstrate that VD can suppress macrophage adhesion and migration by reducing the expression of TREM-1.

Annotation

Disease Annotations    

Gene Ontology Annotations    

Biological Process

Objects Annotated

Genes (Rattus norvegicus)
Trem1  (triggering receptor expressed on myeloid cells 1)

Genes (Mus musculus)
Trem1  (triggering receptor expressed on myeloid cells 1)

Genes (Homo sapiens)
TREM1  (triggering receptor expressed on myeloid cells 1)


Additional Information