RGD Reference Report - An association between single nucleotide polymorphisms within TLR and TREM-1 genes and infective endocarditis. - Rat Genome Database

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An association between single nucleotide polymorphisms within TLR and TREM-1 genes and infective endocarditis.

Authors: Golovkin, Alexey S  Ponasenko, Anastasia V  Yuzhalin, Arseniy E  Salakhov, Ramil R  Khutornaya, Maria V  Kutikhin, Anton G  Rutkovskaya, Natalia V  Savostyanova, Yulia Yu  Barbarash, Leonid S 
Citation: Golovkin AS, etal., Cytokine. 2015 Jan;71(1):16-21. doi: 10.1016/j.cyto.2014.08.001. Epub 2014 Sep 16.
RGD ID: 127229900
Pubmed: PMID:25213166   (View Abstract at PubMed)
DOI: DOI:10.1016/j.cyto.2014.08.001   (Journal Full-text)

Infective endocarditis (IE) is an inflammatory condition of the lining of the heart chambers and valves, which is generally caused by bacteria. Toll-like receptors (TLRs) and Triggering receptor expressed on myeloid cells (TREMs) are key effectors of the innate system that play a significant role in the recognition of infectious agents, particularly, bacteria. We hypothesised that inherited variation in TLR and TREM-1 genes may affect individual susceptibility to IE. The distribution of genotypes and alleles of the TLR1 (rs5743551, rs5743611), TLR2 (rs3804099, rs5743708), TLR4 (rs4986790, rs4986791), TLR6 (rs3775073, rs5743810), and TREM-1 (rs1817537, rs3804277, rs6910730, rs7768162, rs2234246, rs4711668, rs9471535, rs2234237) gene polymorphisms was investigated in 110 Caucasian (Russian) subjects with IE and 300 age-, sex-, and ethnicity-matched healthy blood donors. Odds ratios with 95% confidence intervals were calculated. We found that C/C genotype of the rs3775073 polymorphism within TLR6 gene was associated with a decreased risk of IE (OR=0.51, 95% CI=0.26-0.97, P=0.032) according to the recessive model; however, we observed no association between the other investigated SNPs within TLR and TREM-1 genes and IE. Further in-depth investigations in this field are necessary to shed the light on the impact of inherited variation within innate immune response genes on the development of IE.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
TLR6Humaninfective endocarditis susceptibilityIAGP DNA:SNP:cds:rs3775073(1263A>G)(p.Lys421Lys)(human)RGD 
Tlr6Ratinfective endocarditis susceptibilityISOTLR6 (Homo sapiens)DNA:SNP:cds:rs3775073(1263A>G)(p.Lys421Lys)(human)RGD 
Tlr6Mouseinfective endocarditis susceptibilityISOTLR6 (Homo sapiens)DNA:SNP:cds:rs3775073(1263A>G)(p.Lys421Lys)(human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Tlr6  (toll-like receptor 6)

Genes (Mus musculus)
Tlr6  (toll-like receptor 6)

Genes (Homo sapiens)
TLR6  (toll like receptor 6)


Additional Information