RGD Reference Report - TREM-1 deficiency attenuates the inflammatory responses in LPS-induced murine endometritis. - Rat Genome Database

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TREM-1 deficiency attenuates the inflammatory responses in LPS-induced murine endometritis.

Authors: Zhu, Hongmei  Li, Wenke  Wang, Zhuole  Chen, Jianguo  Ding, Mingxing  Han, Li 
Citation: Zhu H, etal., Microb Biotechnol. 2019 Nov;12(6):1337-1345. doi: 10.1111/1751-7915.13467. Epub 2019 Jul 31.
RGD ID: 126928127
Pubmed: PMID:31365951   (View Abstract at PubMed)
PMCID: PMC6801141   (View Article at PubMed Central)
DOI: DOI:10.1111/1751-7915.13467   (Journal Full-text)

Endometritis, which is usually caused by bacterial infection, is characterized by high levels of pro-inflammatory cytokines and a high infertility rate. Triggering receptor expressed on myeloid cells-1 (TREM-1) has been recognized as a potent amplifier of inflammatory reactions. Studies have demonstrated reduced inflammatory responses and mortality rates of animals with bacterial infection due to the blocking of TREM-1 expression. However, whether TREM-1 deficiency could alleviate the inflammatory reaction in bacterial endometritis is still unclear. Here, TREM-1 knock-out (Trem-1-/- ) mice were used to inhibit TREM-1 signalling to evaluate its role in inflammatory reactions after a highly pathogenic LPS infection in mice uteri. The results demonstrated that TREM-1 deficiency attenuated the inflammation in mice uteri; markedly reduced the number of polymorphonuclear neutrophils; and suppressed interleukin-1β (IL-1β), IL-6, and tumour necrosis factor-α (TNF-α) concentrations in serum as well as their production in inflamed uteri after LPS stimulation. Our results illustrate an anticipated pathogenic impact of TREM-1 on endometritis during LPS infection and indicate that blocking of TREM-1 in LPS-induced endometritis holds considerable promise for blunting excessive inflammation.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
TREM1Humanendometritis amelioratesISOTrem1 (Mus musculus) RGD 
Trem1Ratendometritis amelioratesISOTrem1 (Mus musculus) RGD 
Trem1Mouseendometritis amelioratesIMP  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Trem1  (triggering receptor expressed on myeloid cells 1)

Genes (Mus musculus)
Trem1  (triggering receptor expressed on myeloid cells 1)

Genes (Homo sapiens)
TREM1  (triggering receptor expressed on myeloid cells 1)


Additional Information