RGD Reference Report - Direct-acting antiviral-based triple therapy on alpha-fetoprotein level in chronic hepatitis C patients. - Rat Genome Database

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Direct-acting antiviral-based triple therapy on alpha-fetoprotein level in chronic hepatitis C patients.

Authors: Takayama, Koji  Furusyo, Norihiro  Ogawa, Eiichi  Ikezaki, Hiroaki  Shimizu, Motohiro  Murata, Masayuki  Hayashi, Jun 
Citation: Takayama K, etal., World J Gastroenterol. 2015 Apr 21;21(15):4696-706. doi: 10.3748/wjg.v21.i15.4696.
RGD ID: 126790581
Pubmed: PMID:25914481   (View Abstract at PubMed)
PMCID: PMC4402319   (View Article at PubMed Central)
DOI: DOI:10.3748/wjg.v21.i15.4696   (Journal Full-text)


AIM: To investigate the impact of telaprevir-based triple therapy on the serum alpha-fetoprotein (AFP) level of chronic hepatitis C patients.
METHODS: A total of 210 patients with chronic hepatitis C genotype 1 of high viral load (baseline serum hepatitis C virus RNA > 5.0 log10 IU/mL) were divided into two groups by type of treatment: triple therapy with telaprevir, pegylated-interferon-α (PEG-IFNα), and ribavirin (RBV) for 24 wk (n = 88), or dual therapy with PEG-IFNα and RBV for 48 wk (n = 122). The relationship between virological response and the change in the serum AFP level from baseline to 24 wk after the end of treatment was examined.
RESULTS: No significant difference in mean baseline AFP level was found between the triple and dual therapy groups (8.8 ng/mL vs 7.8 ng/mL). Triple therapy produced significant declines in the AFP level in sustained virological response (SVR) and non-SVR patients (7.8 ng/mL at baseline to 3.5 ng/mL at 24 wk after the end of treatment, P < 0.001 and 14.3 ng/mL to 9.5 ng/mL, P = 0.004, respectively). In contrast, dual therapy resulted in a significant decline in AFP level only in SVR patients (4.7 ng/mL to 2.8 ng/mL, P < 0.001), but not in non-SVR patients (10.2 ng/mL to 10.1 ng/mL). Among patients with a high-baseline AFP level (>= 10 ng/mL), the decline in the AFP level was significantly higher in the triple therapy than in the dual therapy group (15.9 ng/mL vs 1.6 ng/mL, P = 0.037).
CONCLUSION: Regardless of virological response, telaprevir-based triple therapy reduced the serum AFP level.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
hepatitis C treatmentIDA 126790581 RGD 
hepatitis C treatmentISOAFP (Homo sapiens)126790581; 126790581 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Afp  (alpha-fetoprotein)

Genes (Mus musculus)
Afp  (alpha fetoprotein)

Genes (Homo sapiens)
AFP  (alpha fetoprotein)


Additional Information