RGD Reference Report - Deficiency in the frequency and function of Tr1 cells in IgAV and the possible role of IL-27. - Rat Genome Database

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Deficiency in the frequency and function of Tr1 cells in IgAV and the possible role of IL-27.

Authors: Pan, Lu  Wang, Jinghua  Liu, Jinxiang  Guo, Lishuang  Yang, Sirui 
Citation: Pan L, etal., Rheumatology (Oxford). 2020 Dec 6. pii: 6024785. doi: 10.1093/rheumatology/keaa752.
RGD ID: 126790550
Pubmed: PMID:33280050   (View Abstract at PubMed)
PMCID: PMC8516516   (View Article at PubMed Central)
DOI: DOI:10.1093/rheumatology/keaa752   (Journal Full-text)


OBJECTIVE: Type 1 regulatory T (Tr1) cells are involved in the pathogenesis of numerous immune-mediated diseases. However, little is known about whether and how Tr1 cells affect the development of IgA vasculitis (IgAV). We aimed to investigate this question in IgAV patients.
METHODS: . Tr1 cells in peripheral blood and kidney tissue of IgAV patients were analysed by multi-parametric flow cytometry and immunofluorescence techniques. An in vitro assay of suppression of T cell proliferation and cytokine release was performed to evaluate the function of Tr1 cells. Real-time PCR and cell stimulation in vitro were used to explore the roles of IL-27 and early growth response gene 2 (EGR2).
RESULTS: The frequency of Tr1 cells was decreased in peripheral blood but increased in kidney tissue from IgAV patients. A defective suppressive function of Tr1 cells in IgAV was observed. The frequency of Tr1 cells and the cytokines secreted by them were up-regulated in the presence of recombinant IL-27 in vitro. Moreover, IL-27 also increased the expression of EGR2. Furthermore, lower frequency of Tr1 cells during remission had a higher recurrence rate.
CONCLUSION: Tr1 cells are involved in the pathogenesis of IgAV. The low IL-27 in IgAV is responsible for impaired frequency and function of Tr1 cells, and EGR2 may be the specific transcription factor involved in the progression. Tr1 may be a risk factor for IgAV recurrence.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
IL27HumanHenoch-Schoenlein purpura  IEP mRNA more ...RGD 
Il27RatHenoch-Schoenlein purpura  ISOIL27 (Homo sapiens)mRNA more ...RGD 
Il27MouseHenoch-Schoenlein purpura  ISOIL27 (Homo sapiens)mRNA more ...RGD 

Objects Annotated

Genes (Rattus norvegicus)
Il27  (interleukin 27)

Genes (Mus musculus)
Il27  (interleukin 27)

Genes (Homo sapiens)
IL27  (interleukin 27)


Additional Information