RGD Reference Report - The human response to infection is associated with distinct patterns of interleukin 23 and interleukin 27 expression. - Rat Genome Database

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The human response to infection is associated with distinct patterns of interleukin 23 and interleukin 27 expression.

Authors: O'Dwyer, Michael J  Mankan, Arun K  White, Mary  Lawless, Mathew W  Stordeur, Patrick  O'Connell, Brian  Kelleher, Dermot P  McManus, Ross  Ryan, Thomas 
Citation: O'Dwyer MJ, etal., Intensive Care Med. 2008 Apr;34(4):683-91. doi: 10.1007/s00134-007-0968-5. Epub 2008 Jan 29.
RGD ID: 126790544
Pubmed: PMID:18227999   (View Abstract at PubMed)
DOI: DOI:10.1007/s00134-007-0968-5   (Journal Full-text)


OBJECTIVE: The development and progression of severe sepsis is related to a deficiency in pro-inflammatory cytokine production, characterised by lesser IFNgamma levels, which are not explained by variations in levels of the main putative regulator of IFNgamma, namely IL-12. As alternative regulators of IFNgamma may be of greater importance in human sepsis, we investigated the hypothesis that the development of severe sepsis is related to variations in IL-18, IL-23 and IL-27 gene expression.
DESIGN AND SETTING: A prospective observational trial in a mixed intensive care unit (ICU) and hospital wards in a university teaching hospital.
PATIENTS AND PARTICIPANTS: Sixty-two ICU patients with severe sepsis, 13 bacteraemic patients with no acute critical illness, and 10 healthy controls.
MEASUREMENTS AND RESULTS: All subjects were assayed for IL-18, IL-23 and IL-27 mRNA levels in peripheral blood. IL-27 mRNA levels distinguished between the three groups, with levels highest in the ICU group, intermediate in the bacteraemic group and lowest in the control group. IL-23 distinguished between the groups, with levels lowest in the ICU group. In late sepsis IL-23 and TNFalpha mRNA levels were directly related. IL-18 mRNA levels did not distinguish between the patient groups.
CONCLUSIONS: We conclude that the deficient pro-inflammatory response in patients with sepsis is expansive and includes deficient IL-23 and excessive IL-27 gene expression. This provides further evidence that upregulation of a cytokine-based immune response is beneficial in sepsis.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
IL27HumanSepsis  IEP mRNA:increased expression:blood, leukocyte (human)RGD 
Il27RatSepsis  ISOIL27 (Homo sapiens)mRNA:increased expression:blood, leukocyte (human)RGD 
Il27MouseSepsis  ISOIL27 (Homo sapiens)mRNA:increased expression:blood, leukocyte (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Il27  (interleukin 27)

Genes (Mus musculus)
Il27  (interleukin 27)

Genes (Homo sapiens)
IL27  (interleukin 27)


Additional Information