RGD Reference Report - The correlation between hepatitis B virus infection and IL-27. - Rat Genome Database

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The correlation between hepatitis B virus infection and IL-27.

Authors: Wang, Hong-Liang  Zhang, Hai-Yan  Zhai, Zhong-Liang  Zhou, Xin 
Citation: Wang HL, etal., Biomed Mater Eng. 2012;22(1-3):187-93. doi: 10.3233/BME-2012-0706.
RGD ID: 126790543
Pubmed: PMID:22766719   (View Abstract at PubMed)
DOI: DOI:10.3233/BME-2012-0706   (Journal Full-text)


OBJECTIVE: To investigate the correlation between HBV infection and interleukin 27 (IL-27).
METHODS: Serum IL-27 levels in patients with HBV infection and in healthy individuals were measured by ELISA, regulation of IL-27 by HBV in vitro were analyzed by RT-PCR and ELISA.
RESULTS: IL-27 was significantly elevated in patients as compared to healthy individuals (P<0.001). IL-27 was also detected at higher levels in patients with liver cirrhosis or hepatocellular carcinoma than those with acute hepatitis B or chronic hepatitis B (P<0.05). We also found that IL-27 expression was influenced by HBV e antigen. In addition, our in vitro studies demonstrated that mRNA and protein expression were all stimulated in cells transfected with infectious HBV clone.
CONCLUSIONS: IL-27 would be a novel cytokine for clinical management of HBV-infected patients, which may establish novel HBV therapeutic approaches.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
IL27Humanhepatitis B  IEP protein:increased expression:blood serum (human)RGD 
Il27Rathepatitis B  ISOIL27 (Homo sapiens)protein:increased expression:blood serum (human)RGD 
Il27Mousehepatitis B  ISOIL27 (Homo sapiens)protein:increased expression:blood serum (human)RGD 
IL27HumanNeonatal Sepsis  IEP protien:increased expression:blood serum (human)RGD 
Il27RatNeonatal Sepsis  ISOIL27 (Homo sapiens)protien:increased expression:blood serum (human)RGD 
Il27MouseNeonatal Sepsis  ISOIL27 (Homo sapiens)protien:increased expression:blood serum (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Il27  (interleukin 27)

Genes (Mus musculus)
Il27  (interleukin 27)

Genes (Homo sapiens)
IL27  (interleukin 27)


Additional Information