RGD Reference Report - IL-27 Suppresses Antimicrobial Activity in Human Leprosy. - Rat Genome Database

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IL-27 Suppresses Antimicrobial Activity in Human Leprosy.

Authors: Teles, Rosane M B  Kelly-Scumpia, Kindra M  Sarno, Euzenir N  Rea, Thomas H  Ochoa, Maria T  Cheng, Genhong  Modlin, Robert L 
Citation: Teles RMB, etal., J Invest Dermatol. 2015 Oct;135(10):2410-2417. doi: 10.1038/jid.2015.195. Epub 2015 Jun 1.
RGD ID: 126790539
Pubmed: PMID:26030183   (View Abstract at PubMed)
PMCID: PMC4567935   (View Article at PubMed Central)
DOI: DOI:10.1038/jid.2015.195   (Journal Full-text)

The mechanisms by which intracellular pathogens trigger immunosuppressive pathways are critical for understanding the pathogenesis of microbial infection. One pathway that inhibits host defense responses involves the induction of type I interferons and subsequently IL-10, yet the mechanism by which type I IFN induces IL-10 remains unclear. Our studies of gene expression profiles derived from leprosy skin lesions suggested a link between IL-27 and the IFN-β induced IL-10 pathway. Here, we demonstrate that the IL-27p28 subunit is upregulated following treatment of monocytes with IFN-β and Mycobacterium leprae, the intracellular bacterium that causes leprosy. The ability of IFN-β and M. leprae to induce IL-10 was diminished by IL-27 knockdown. Additionally, treatment of monocytes with recombinant IL-27 was sufficient to induce the production of IL-10. Functionally, IL-27 inhibited the ability of IFN-γ to trigger antimicrobial activity against M. leprae in infected monocytes. At the site of disease, IL-27 was more strongly expressed in skin lesions of patients with progressive lepromatous leprosy, correlating and colocalizing with IFN-β and IL-10 in macrophages. Together, these data provide evidence that in the human cutaneous immune responses to microbial infection, IL-27 contributes to the suppression of host antimicrobial responses.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
IL27Humanlepromatous leprosy amelioratesIEP mRNA:decreased expression:skin of body (human)RGD 
Il27Ratlepromatous leprosy amelioratesISOIL27 (Homo sapiens)mRNA:decreased expression:skin of body (human)RGD 
Il27Mouselepromatous leprosy amelioratesISOIL27 (Homo sapiens)mRNA:decreased expression:skin of body (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Il27  (interleukin 27)

Genes (Mus musculus)
Il27  (interleukin 27)

Genes (Homo sapiens)
IL27  (interleukin 27)


Additional Information