RGD Reference Report - Relationship of IL27 gene polymorphisms with the risk of pulmonary tuberculosis in Chinese Han population. - Rat Genome Database

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Relationship of IL27 gene polymorphisms with the risk of pulmonary tuberculosis in Chinese Han population.

Authors: He, Chenyan  Liu, Jincheng 
Citation: He C and Liu J, Int J Clin Exp Pathol. 2018 Aug 1;11(8):4147-4152. eCollection 2018.
RGD ID: 126790508
Pubmed: PMID:31949807   (View Abstract at PubMed)
PMCID: PMC6962794   (View Article at PubMed Central)


OBJECTIVE: The aim of this study was to explore the effect of human interleukin-27 (IL-27) gene polymorphisms -964A/G and 2095T/G on the development of pulmonary tuberculosis (PTB), and its radiographic characteristics and severity.
METHODS: A case-control study was performed in 123 PTB patients and 110 healthy controls. Differences in genotype and allele distributions of the two polymorphisms were analyzed via chi-square test between PTB patients and controls, between patients with single- and multi-lobe involvement, and between patients with and without cavities.
RESULTS: Significant differences were found in the genotype and allele distributions of -964A/G (P<0.05), in which GG genotype carriers were more common in PTB patients. In addition, the -964AA genotype was more prevalent in patients with single-lobe involvement compare with those with multi-lobe involvement (51.355 vs. 30.30%, P=0.035), as well as the 2095TT genotype (89.19% vs. 71.21, P=0.036). But there were no significant differences between patients with or without cavitations in either polymorphisms (P>0.05).
CONCLUSION: IL-27 gene polymorphism -964A/G was correlated with PTB susceptibility, and G allele might be a risk factor for the disease onset. Furthermore, the -964AA genotype might be associated with a protective role that limits the intrapulmonary spread of TB in Chinese population. But the role of 2095T/G was not sure.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
IL27Humanpulmonary tuberculosis exacerbatesIAGP DNA:SNPs:promoter, exon:-964A>G, 2905T>G (human)RGD 
Il27Ratpulmonary tuberculosis exacerbatesISOIL27 (Homo sapiens)DNA:SNPs:promoter, exon:-964A>G, 2905T>G (human)RGD 
Il27Mousepulmonary tuberculosis exacerbatesISOIL27 (Homo sapiens)DNA:SNPs:promoter, exon:-964A>G, 2905T>G (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Il27  (interleukin 27)

Genes (Mus musculus)
Il27  (interleukin 27)

Genes (Homo sapiens)
IL27  (interleukin 27)


Additional Information