RGD Reference Report - Sleep/Wake Physiology and Quantitative Electroencephalogram Analysis of the Neuroligin-3 Knockout Rat Model of Autism Spectrum Disorder. - Rat Genome Database

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Sleep/Wake Physiology and Quantitative Electroencephalogram Analysis of the Neuroligin-3 Knockout Rat Model of Autism Spectrum Disorder.

Authors: Thomas, Alexia M  Schwartz, Michael D  Saxe, Michael D  Kilduff, Thomas S 
Citation: Thomas AM, etal., Sleep. 2017 Oct 1;40(10). pii: 4100612. doi: 10.1093/sleep/zsx138.
RGD ID: 126790492
Pubmed: PMID:28958035   (View Abstract at PubMed)
DOI: DOI:10.1093/sleep/zsx138   (Journal Full-text)


Study Objectives: Neuroligin-3 (NLGN3) is one of the many genes associated with autism spectrum disorder (ASD). Sleep dysfunction is highly prevalent in ASD, but has not been rigorously examined in ASD models. Here, we evaluated sleep/wake physiology and behavioral phenotypes of rats with genetic ablation of Nlgn3.
Methods: Male Nlgn3 knockout (KO) and wild-type (WT) rats were assessed using a test battery for ASD-related behaviors and also implanted with telemeters to record the electroencephalogram (EEG), electromyogram, body temperature, and locomotor activity. 24-h EEG recordings were analyzed for sleep/wake states and spectral composition.
Results: Nlgn3 KO rats were hyperactive, exhibited excessive chewing behavior, and had impaired prepulse inhibition to an auditory startle stimulus. KO rats also spent less time in non-rapid eye movement (NREM) sleep, more time in rapid eye movement (REM) sleep, exhibited elevated theta power (4-9 Hz) during wakefulness and REM, and elevated delta power (0.5-4 Hz) during NREM. Beta (12-30 Hz) power and gamma (30-50 Hz) power were suppressed across all vigilance states.
Conclusions: The sleep disruptions in Nlgn3 KO rats are consistent with observations of sleep disturbances in ASD patients. The EEG provides objective measures of brain function to complement rodent behavioral analyses and therefore may be a useful tool to study ASD.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Nlgn3Ratcircadian sleep/wake cycle  IMP  RGD 
Nlgn3Ratprepulse inhibition  IMP  RGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Nlgn3Ratabnormal brain wave pattern  IMP  RGD 
Nlgn3em1SageRatabnormal brain wave pattern  IMP  RGD 
SD-Nlgn3em1SageRatabnormal brain wave pattern  IMP  RGD 
Nlgn3Ratabnormal non-rapid eye movement sleep pattern  IMP during light cycleRGD 
Nlgn3em1SageRatabnormal non-rapid eye movement sleep pattern  IMP during light cycleRGD 
SD-Nlgn3em1SageRatabnormal non-rapid eye movement sleep pattern  IMP during light cycleRGD 
Nlgn3Ratabnormal paradoxical sleep pattern  IMP during light cycleRGD 
Nlgn3em1SageRatabnormal paradoxical sleep pattern  IMP during light cycleRGD 
SD-Nlgn3em1SageRatabnormal paradoxical sleep pattern  IMP during light cycleRGD 
Nlgn3Ratabnormal social investigation  IMP  RGD 
Nlgn3em1SageRatabnormal social investigation  IMP  RGD 
SD-Nlgn3em1SageRatabnormal social investigation  IMP  RGD 
Nlgn3Ratabnormal social play behavior  IMP  RGD 
Nlgn3em1SageRatabnormal social play behavior  IMP  RGD 
SD-Nlgn3em1SageRatabnormal social play behavior  IMP  RGD 
Nlgn3Ratdecreased body weight  IMP  RGD 
Nlgn3em1SageRatdecreased body weight  IMP  RGD 
SD-Nlgn3em1SageRatdecreased body weight  IMP  RGD 
Nlgn3Ratdecreased prepulse inhibition  IMP  RGD 
Nlgn3em1SageRatdecreased prepulse inhibition  IMP  RGD 
SD-Nlgn3em1SageRatdecreased prepulse inhibition  IMP  RGD 
Nlgn3Rathyperactivity  IMP  RGD 
Nlgn3em1SageRathyperactivity  IMP  RGD 
SD-Nlgn3em1SageRathyperactivity  IMP  RGD 
Nlgn3Ratincreased anxiety-related response  IMP  RGD 
Nlgn3em1SageRatincreased anxiety-related response  IMP  RGD 
SD-Nlgn3em1SageRatincreased anxiety-related response  IMP  RGD 
Nlgn3Ratincreased gnawing activity  IMP  RGD 
Nlgn3em1SageRatincreased gnawing activity  IMP  RGD 
SD-Nlgn3em1SageRatincreased gnawing activity  IMP  RGD 
Objects Annotated

Genes (Rattus norvegicus)
Nlgn3  (neuroligin 3)
Nlgn3em1Sage  (neuroligin 3; zinc finger nuclease induced mutant 1, Sigma Advanced Genetic Engineering Labs)

Genes (Mus musculus)
Nlgn3  (neuroligin 3)

Genes (Homo sapiens)
NLGN3  (neuroligin 3)

Strains
SD-Nlgn3em1Sage  (NA)


Additional Information