RGD Reference Report - Lipocalin 2 modulates the cellular response to amyloid beta. - Rat Genome Database

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Lipocalin 2 modulates the cellular response to amyloid beta.

Authors: Mesquita, S D  Ferreira, A C  Falcao, A M  Sousa, J C  Oliveira, T G  Correia-Neves, M  Sousa, N  Marques, F  Palha, J A 
Citation: Mesquita SD, etal., Cell Death Differ. 2014 Oct;21(10):1588-99. doi: 10.1038/cdd.2014.68. Epub 2014 May 23.
RGD ID: 126781834
Pubmed: PMID:24853299   (View Abstract at PubMed)
PMCID: PMC4158684   (View Article at PubMed Central)
DOI: DOI:10.1038/cdd.2014.68   (Journal Full-text)

The production, accumulation and aggregation of amyloid beta (Aβ) peptides in Alzheimer's disease (AD) are influenced by different modulators. Among these are iron and iron-related proteins, given their ability to modulate the expression of the amyloid precursor protein and to drive Aβ aggregation. Herein, we describe that lipocalin 2 (LCN2), a mammalian acute-phase protein involved in iron homeostasis, is highly produced in response to Aβ1-42 by choroid plexus epithelial cells and astrocytes, but not by microglia or neurons. Although Aβ1-42 stimulation decreases the dehydrogenase activity and survival of wild-type astrocytes, astrocytes lacking the expression of Lcn2 are not affected. This protection results from a lower expression of the proapoptotic gene Bim and a decreased inflammatory response. Altogether, these findings show that Aβ toxicity to astrocytes requires LCN2, which represents a novel mechanism to target when addressing AD.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
cellular response to amyloid-beta  IEP 126781834 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Lcn2  (lipocalin 2)


Additional Information