RGD Reference Report - Combined biomarkers evaluation for diagnosing kidney injury in preeclampsia. - Rat Genome Database

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Combined biomarkers evaluation for diagnosing kidney injury in preeclampsia.

Authors: Xiao, Jing  Niu, Jianying  Ye, Xianwu  Yu, Qianqian  Gu, Yong 
Citation: Xiao J, etal., Hypertens Pregnancy. 2013 Nov;32(4):439-49. doi: 10.3109/10641955.2013.827203. Epub 2013 Aug 19.
RGD ID: 126781721
Pubmed: PMID:23957217   (View Abstract at PubMed)
DOI: DOI:10.3109/10641955.2013.827203   (Journal Full-text)


OBJECTIVE: To identify novel potential biomarkers and evaluate combined biomarkers for diagnosing kidney injury with considerable accuracy in preeclampsia.
METHODS: The level of serum and urine neutrophil gelatinase-associated lipocalin (NGAL), kidney injury molecule-1 (KIM-1), retinol-binding protein (RBP) and interleukin-18 (IL-18) were measured by enzyme-linked immunosorbent assay.
RESULTS: The level of serum cystatin C, urine RBP, urine NGAL and urine KIM-1 in preeclampsia group were higher than that in the normal pregnancy group. When four biomarkers are combined, the sensitivity and specificity are 100%/98.20%.
CONCLUSION: Urine KIM-1 is the most potential biomarker for renal injury in preeclampsia. The more biomarkers combined, the more sensitivity and specificity were increased.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
pre-eclampsia  IEP 126781721protein:increased expression:serum and urineRGD 
pre-eclampsia  ISOLCN2 (Homo sapiens)126781721; 126781721protein:increased expression:serum and urineRGD 

Objects Annotated

Genes (Rattus norvegicus)
Lcn2  (lipocalin 2)

Genes (Mus musculus)
Lcn2  (lipocalin 2)

Genes (Homo sapiens)
LCN2  (lipocalin 2)


Additional Information