RGD Reference Report - Lipocalin 2-deficient mice exhibit increased sensitivity to Escherichia coli infection but not to ischemia-reperfusion injury. - Rat Genome Database

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Lipocalin 2-deficient mice exhibit increased sensitivity to Escherichia coli infection but not to ischemia-reperfusion injury.

Authors: Berger, Thorsten  Togawa, Atsushi  Duncan, Gordon S  Elia, Andrew J  You-Ten, Annick  Wakeham, Andrew  Fong, Hannah E H  Cheung, Carol C  Mak, Tak W 
Citation: Berger T, etal., Proc Natl Acad Sci U S A. 2006 Feb 7;103(6):1834-9. doi: 10.1073/pnas.0510847103. Epub 2006 Jan 30.
RGD ID: 126779557
Pubmed: PMID:16446425   (View Abstract at PubMed)
PMCID: PMC1413671   (View Article at PubMed Central)
DOI: DOI:10.1073/pnas.0510847103   (Journal Full-text)

Diverse functions have been reported for lipocalin 2. To investigate these functions in vivo, we generated gene-targeted lipocalin 2-deficient mice (Lcn2-/- mice). In vitro studies have suggested that lipocalin 2 is important for cellular apoptosis induced by IL-3 withdrawal, and for the induction of kidney differentiation during embryogenesis. Analysis of Lcn2-/- mice showed normal cell death upon IL-3 withdrawal and normal kidney development. However, we found that Lcn2-/- mice exhibited an increased susceptibility to bacterial infections, in keeping with the proposed function of lipocalin 2 in iron sequestration. Neutrophils isolated from Lcn2-/- mice showed significantly less bacteriostatic activity compared with WT controls. The bacteriostatic property of the WT neutrophils was abolished by the addition of exogenous iron, indicating that the main function of lipocalin 2 in the antibacterial innate immune response is to limit this essential element. Another important function ascribed to lipocalin 2 has been its protective role against kidney ischemia-reperfusion injury. We analyzed Lcn2-/- mice using a mouse model for severe renal failure and could not detect any significant differences compared with their WT littermates.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Escherichia Coli Infections exacerbatesISOLcn2 (Mus musculus)126779557; 126779557 RGD 
Escherichia Coli Infections exacerbatesIMP 126779557 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Lcn2  (lipocalin 2)

Genes (Mus musculus)
Lcn2  (lipocalin 2)

Genes (Homo sapiens)
LCN2  (lipocalin 2)


Additional Information