RGD Reference Report - ADAR1 overexpression is associated with cervical cancer progression and angiogenesis. - Rat Genome Database

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ADAR1 overexpression is associated with cervical cancer progression and angiogenesis.

Authors: Chen, Ying  Wang, He  Lin, Wenyi  Shuai, Ping 
Citation: Chen Y, etal., Diagn Pathol. 2017 Jan 21;12(1):12. doi: 10.1186/s13000-017-0600-0.
RGD ID: 125097518
Pubmed: PMID:28109322   (View Abstract at PubMed)
PMCID: PMC5251241   (View Article at PubMed Central)
DOI: DOI:10.1186/s13000-017-0600-0   (Journal Full-text)


BACKGROUND: This study aimed to assess the role of RNA-dependent adenosine deaminase (ADAR1) in cervical squamous cell carcinoma occurrence and progression.
METHODS: ADAR1 expression levels in stage IA and stage IIA cervical squamous cell carcinoma (group A), cervical intraepithelial neoplasia (CIN) specimens (group B), as well as normal and inflamed cervical tissue samples (group C) were assessed by immunohistochemistry. Clinical and pathological data of cervical squamous cell carcinoma patients undergoing surgery were retrospectively evaluated. Chi-square test, comparative analysis of survival curve, disease-free survival and COX risk assessment method were used to understand the association of ADAR1 with the occurrence and progression and prognostic significance of cervical squamous cell carcinoma.
RESULTS: ADAR1 is expressed in the cytoplasm and nuclei. The expression level was high in squamous cell carcinoma tissues (81.18%), while relatively low in the CIN group (21.56%). And there was no expression in non-cancerous tissues. The differences between them were statistically significant using P < 0.05 as criterion. One-factor analysis revealed that ADAR1 was significantly correlated with tumor diameter, horizontal diffusion diameter, vascular invasion, parametrial invasion, vaginal involvement, and pathologically diagnostic criteria for perineural invasion (PNI). Meanwhile, the overall survival rate of ADAR1 positive patients was significantly lower compared with that of patients with no ADAR1 expression (P < 0.05). Analysis also showed that disease-free survival time of ADAR1 positive patients was shorter than that of ADAR1 negative patients, and the difference was significant (P < 0.01). Finally, COX risk assessment showed that parametrical invasion had independent prognostic factors for overall survival of squamous cell carcinoma.
CONCLUSIONS: Results indicated that ADAR1 might play an important role in the occurrence, progression and prognosis of cervical squamous cancer.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
cervical squamous cell carcinoma disease_progressionIEP 125097518protein:increased expression:cervix squamous epithelium (human)RGD 
cervical squamous cell carcinoma disease_progressionISOADAR (Homo sapiens)125097518; 125097518protein:increased expression:cervix squamous epithelium (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Adar  (adenosine deaminase, RNA-specific)

Genes (Mus musculus)
Adar  (adenosine deaminase, RNA-specific)

Genes (Homo sapiens)
ADAR  (adenosine deaminase RNA specific)


Additional Information