RGD Reference Report - Increasing numbers of synaptic puncta during late-phase LTP: N-cadherin is synthesized, recruited to synaptic sites, and required for potentiation. - Rat Genome Database

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Increasing numbers of synaptic puncta during late-phase LTP: N-cadherin is synthesized, recruited to synaptic sites, and required for potentiation.

Authors: Bozdagi, O  Shan, W  Tanaka, H  Benson, D L  Huntley, G W 
Citation: Bozdagi O, etal., Neuron. 2000 Oct;28(1):245-59.
RGD ID: 12050097
Pubmed: PMID:11086998   (View Abstract at PubMed)

It is an open question whether new synapses form during hippocampal LTP. Here, we show that late-phase LTP (L-LTP) is associated with a significant increase in numbers of synaptic puncta identified by synaptophysin and N-cadherin, an adhesion protein involved in synapse formation during development. During potentiation, protein levels of N-cadherin are significantly elevated and N-cadherin dimerization is enhanced. The increases in synaptic number and N-cadherin levels are dependent on cAMP-dependent protein kinase (PKA) and protein synthesis, both of which are also required for L-LTP. Blocking N-cadherin adhesion prevents the induction of L-LTP, but not the early-phase of LTP (E-LTP). Our data suggest that N-cadherin is synthesized during the induction of L-LTP and recruited to newly forming synapses. N-cadherin may play a critical role in L-LTP by holding nascent pre-and postsynaptic membranes in apposition, enabling incipient synapses to acquire function and contribute to potentiation.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
synaptic membrane adhesion involved_inICGO:0016339 more ...12050097PMID:11086998SynGO 

Cellular Component
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
postsynaptic specialization membrane located_inIDA 12050097PMID:11086998SynGO 
presynaptic active zone membrane located_inIDA 12050097PMID:11086998SynGO 

Objects Annotated

Genes (Rattus norvegicus)
Cdh2  (cadherin 2)


Additional Information