RGD Reference Report - GABA promotes the competitive selection of dendritic spines by controlling local Ca2+ signaling. - Rat Genome Database

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GABA promotes the competitive selection of dendritic spines by controlling local Ca2+ signaling.

Authors: Hayama, T  Noguchi, J  Watanabe, S  Takahashi, N  Hayashi-Takagi, A  Ellis-Davies, GC  Matsuzaki, M  Kasai, H 
Citation: Hayama T, etal., Nat Neurosci. 2013 Oct;16(10):1409-16. doi: 10.1038/nn.3496. Epub 2013 Aug 25.
RGD ID: 11570553
Pubmed: (View Article at PubMed) PMID:23974706
DOI: Full-text: DOI:10.1038/nn.3496

Activity-dependent competition of synapses plays a key role in neural organization and is often promoted by GABA; however, its cellular bases are poorly understood. Excitatory synapses of cortical pyramidal neurons are formed on small protrusions known as dendritic spines, which exhibit structural plasticity. We used two-color uncaging of glutamate and GABA in rat hippocampal CA1 pyramidal neurons and found that spine shrinkage and elimination were markedly promoted by the activation of GABAA receptors shortly before action potentials. GABAergic inhibition suppressed bulk increases in cytosolic Ca(2+) concentrations, whereas it preserved the Ca(2+) nanodomains generated by NMDA-type receptors, both of which were necessary for spine shrinkage. Unlike spine enlargement, spine shrinkage spread to neighboring spines (<15 mum) and competed with their enlargement, and this process involved the actin-depolymerizing factor ADF/cofilin. Thus, GABAergic inhibition directly suppresses local dendritic Ca(2+) transients and strongly promotes the competitive selection of dendritic spines.



Gene Ontology Annotations    

Biological Process

Objects Annotated

Genes (Rattus norvegicus)
Cfl1  (cofilin 1)


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