RGD Reference Report - Exercise increases mRNA levels for adhesion molecules N-CAM and L1 correlating with BDNF response. - Rat Genome Database

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Exercise increases mRNA levels for adhesion molecules N-CAM and L1 correlating with BDNF response.

Authors: Macias, M  Fehr, S  Dwornik, A  Sulejczak, D  Wiater, M  Czarkowska-Bauch, J  Skup, M  Schachner, M 
Citation: Macias M, etal., Neuroreport. 2002 Dec 20;13(18):2527-30.
RGD ID: 11570528
Pubmed: PMID:12499861   (View Abstract at PubMed)
DOI: DOI:10.1097/01.wnr.0000047689.08940.ef   (Journal Full-text)

In situ hybridization was used to evaluate whether long-term moderate locomotor exercise, which up-regulates BDNF and TrkB levels in the spinal gray matter of the adult rat, similarly influences the expression of the cell adhesion molecules N-CAM and L1. Exercise doubled the level of N-CAM mRNA hybridization signal in the lumbar spinal gray. The increase in L1 mRNA was less consistent. N-CAM mRNA levels slightly increased in the white matter. BDNF mRNA levels also increased in cells of the ventral horn and the white matter due to the exercise. These results suggest that exercise-induced rearrangements of the spinal network involve N-CAM, L1 and BDNF, crucial in different aspects of synaptic plasticity and synapse formation.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
L1camRatresponse to activity  IEP  RGD 
Ncam1Ratresponse to activity  IEP  RGD 

Objects Annotated

Genes (Rattus norvegicus)
L1cam  (L1 cell adhesion molecule)
Ncam1  (neural cell adhesion molecule 1)


Additional Information