RGD Reference Report - Hay-Wells syndrome is caused by heterozygous missense mutations in the SAM domain of p63. - Rat Genome Database

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Hay-Wells syndrome is caused by heterozygous missense mutations in the SAM domain of p63.

Authors: McGrath, JA  Duijf, PH  Doetsch, V  Irvine, AD  De Waal, R  Vanmolkot, KR  Wessagowit, V  Kelly, A  Atherton, DJ  Griffiths, WA  Orlow, SJ  Van Haeringen, A  Ausems, MG  Yang, A  McKeon, F  Bamshad, MA  Brunner, HG  Hamel, BC  Van Bokhoven, H 
Citation: McGrath JA, etal., Hum Mol Genet. 2001 Feb 1;10(3):221-9.
RGD ID: 11568643
Pubmed: PMID:11159940   (View Abstract at PubMed)

Hay-Wells syndrome, also known as ankyloblepharon-ectodermal dysplasia-clefting (AEC) syndrome (OMIM 106260), is a rare autosomal dominant disorder characterized by congenital ectodermal dysplasia, including alopecia, scalp infections, dystrophic nails, hypodontia, ankyloblepharon and cleft lip and/or cleft palate. This constellation of clinical signs is unique, but some overlap can be recognized with other ectodermal dysplasia syndromes, for example ectrodactyly--ectodermal dysplasia--cleft lip/palate (EEC; OMIM 604292), limb--mammary syndrome (LMS; OMIM 603543), acro-dermato-ungual-lacrimal-tooth syndrome (ADULT; OMIM 103285) and recessive cleft lip/palate--ectodermal dysplasia (CLPED1; OMIM 225060). We have recently demonstrated that heterozygous mutations in the p63 gene are the major cause of EEC syndrome. Linkage studies suggest that the related LMS and ADULT syndromes are also caused by mutations in the p63 gene. Thus, it appears that p63 gene mutations have highly pleiotropic effects. We have analysed p63 in AEC syndrome patients and identified missense mutations in eight families. All mutations give rise to amino acid substitutions in the sterile alpha motif (SAM) domain, and are predicted to affect protein--protein interactions. In contrast, the vast majority of the mutations found in EEC syndrome are amino acid substitutions in the DNA-binding domain. Thus, a clear genotype--phenotype correlation can be recognized for EEC and AEC syndromes.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
TP63Humanankyloblepharon-ectodermal defects-cleft lip/palate syndrome  IAGP DNA:missense mutations:exon:multipleRGD 
Tp63Ratankyloblepharon-ectodermal defects-cleft lip/palate syndrome  ISOTP63 (Homo sapiens)DNA:missense mutations:exon:multipleRGD 
Trp63Mouseankyloblepharon-ectodermal defects-cleft lip/palate syndrome  ISOTP63 (Homo sapiens)DNA:missense mutations:exon:multipleRGD 

Objects Annotated

Genes (Rattus norvegicus)
Tp63  (tumor protein p63)

Genes (Mus musculus)
Trp63  (transformation related protein 63)

Genes (Homo sapiens)
TP63  (tumor protein p63)


Additional Information