Effect of thyroxine on the activity of mitochondrial cardiolipin synthase in rat liver.
||Hostetler KY Biochim Biophys Acta. 1991 Oct 15;1086(1):139-40.
||(View Article at PubMed) PMID:1659453
Cardiolipin is a major mitochondrial membrane lipid and plays a vital role in mitochondrial function. The effect of thyroxine on the activity of liver mitochondrial cardiolipin synthase was examined in this study. Treatment with thyroxine (250 micrograms/100 g) for 5 days increased cardiolipin synthase activity by 52%. Mitochondrial levels of cardiolipin appear to be regulated in part by the effect of thyroid hormone on the activity of cardiolipin synthase.