RGD Reference Report - Triad3A regulates synaptic strength by ubiquitination of Arc. - Rat Genome Database

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Triad3A regulates synaptic strength by ubiquitination of Arc.

Authors: Mabb, AM  Je, HS  Wall, MJ  Robinson, CG  Larsen, RS  Qiang, Y  Correa, SA  Ehlers, MD 
Citation: Mabb AM, etal., Neuron. 2014 Jun 18;82(6):1299-316. doi: 10.1016/j.neuron.2014.05.016.
RGD ID: 11553202
Pubmed: PMID:24945773   (View Abstract at PubMed)
PMCID: PMC4277707   (View Article at PubMed Central)
DOI: DOI:10.1016/j.neuron.2014.05.016   (Journal Full-text)

Activity-dependent gene transcription and protein synthesis underlie many forms of learning-related synaptic plasticity. At excitatory glutamatergic synapses, the immediate early gene product Arc/Arg3.1 couples synaptic activity to postsynaptic endocytosis of AMPA-type glutamate receptors. Although the mechanisms for Arc induction have been described, little is known regarding the molecular machinery that terminates Arc function. Here, we demonstrate that the RING domain ubiquitin ligase Triad3A/RNF216 ubiquitinates Arc, resulting in its rapid proteasomal degradation. Triad3A associates with Arc, localizes to clathrin-coated pits, and is associated with endocytic sites in dendrites and spines. In the absence of Triad3A, Arc accumulates, leading to the loss of surface AMPA receptors. Furthermore, loss of Triad3A mimics and occludes Arc-dependent forms of synaptic plasticity. Thus, degradation of Arc by clathrin-localized Triad3A regulates the availability of synaptic AMPA receptors and temporally tunes Arc-mediated plasticity at glutamatergic synapses.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

Cellular Component
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
glutamatergic synapse is_active_inIDA 11553202PMID:24945773SynGO 
glutamatergic synapse is_active_inIMP 11553202PMID:24945773SynGO 
postsynaptic endocytic zone is_active_inIDA 11553202PMID:24945773SynGO 
presynapse is_active_inIDA 11553202PMID:24945773SynGO 
Schaffer collateral - CA1 synapse is_active_inIDA 11553202PMID:24945773SynGO 

Objects Annotated

Genes (Rattus norvegicus)
Rnf216  (ring finger protein 216)


Additional Information