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Association between FOXP2 polymorphisms and schizophrenia with auditory hallucinations.

Authors: Sanjuan, J  Tolosa, A  Gonzalez, JC  Aguilar, EJ  Perez-Tur, J  Najera, C  Molto, MD  De Frutos, R 
Citation: Sanjuan J, etal., Psychiatr Genet. 2006 Apr;16(2):67-72.
Pubmed: (View Article at PubMed) PMID:16538183
DOI: Full-text: DOI:10.1097/

OBJECTIVE: A mutation in the FOXP2 gene has been the first genetic association with a language disorder. Language disorder is considered as a core symptom of schizophrenia. Therefore, the FOXP2 gene could be considered a good candidate gene for the vulnerability to schizophrenia. METHODS: A set of single nucleotide polymorphisms mainly located in the 5' regulatory region of the FOXP2 gene was analysed in a sample of 186 DSM-IV schizophrenic patients with auditory hallucinations and in 160 healthy controls. RESULTS: Statistically significant differences in the genotype (P=0.007) and allele frequencies (P=0.0027) between schizophrenic patients with auditory hallucinations and controls were found in the single nucleotide polymorphism rs2396753. These P values changed to 0.07 and 0.0273, respectively, after Bonferroni sequential correction. The haplotype rs7803667T/rs10447760C/rs923875A/rs1358278A/rs2396753A (TCAAA) also showed a significant difference confirmed with a permutation test (P=0.009). CONCLUSIONS: These results suggested that the FOXP2 gene may confer vulnerability to schizophrenic patients with auditory hallucinations.


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RGD Object Information
RGD ID: 11535988
Created: 2016-09-27
Species: All species
Last Modified: 2016-09-27
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.