RGD Reference Report - Manifestation of multidrug resistance protein 3 (MRP3) in liver and kidney cells in cholestasis: effects of hyperprolactinemia. - Rat Genome Database

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Manifestation of multidrug resistance protein 3 (MRP3) in liver and kidney cells in cholestasis: effects of hyperprolactinemia.

Authors: Aleksandrova, MI  Kushnareva, NS  Smirnova, OV 
Citation: Aleksandrova MI, etal., Bull Exp Biol Med. 2013 Feb;154(4):508-11.
RGD ID: 11535162
Pubmed: PMID:23486593   (View Abstract at PubMed)

Immunohistochemistry with semiquantitative image analysis showed that cholestasis induced an increase in the manifestation of mrp3 in cholangiocytes of female rats, but did not affect this parameter in the studied structures of kidney. Under conditions of normal liver function, mrp3 expression in cholangiocytes was also elevated during hyperprolactinemia. Expression of mrp3 in cholangiocytes directly correlated with prolactin receptor expression. In cholestasis, prolactin increased mrp3 manifestation of only in the distal renal tubules. Thus, mrp3 manifestation increases in liver cells, but remains unchanged in kidney cells. The hyperprolactinemia-induced changes in the mrp3 levels and their correlations with prolactin receptor expression were shown to differ in the kidney and liver cells. It was hypothesized that prolactin produced a direct effect on mrp3 expression in cholangiocytes.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
ABCC3Humancholestasis  ISOAbcc3 (Rattus norvegicus)protein:increased expression:liverRGD 
Abcc3Ratcholestasis  IEP protein:increased expression:liverRGD 
Abcc3Mousecholestasis  ISOAbcc3 (Rattus norvegicus)protein:increased expression:liverRGD 
ABCC3Humanhyperprolactinemia  ISOAbcc3 (Rattus norvegicus)protein:increased expression:liverRGD 
Abcc3Rathyperprolactinemia  IEP protein:increased expression:liverRGD 
Abcc3Mousehyperprolactinemia  ISOAbcc3 (Rattus norvegicus)protein:increased expression:liverRGD 

Objects Annotated

Genes (Rattus norvegicus)
Abcc3  (ATP binding cassette subfamily C member 3)

Genes (Mus musculus)
Abcc3  (ATP-binding cassette, sub-family C member 3)

Genes (Homo sapiens)
ABCC3  (ATP binding cassette subfamily C member 3)


Additional Information