RGD Reference Report - p110alpha and p110beta isoforms of PI3K signaling: are they two sides of the same coin? - Rat Genome Database

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p110alpha and p110beta isoforms of PI3K signaling: are they two sides of the same coin?

Authors: Singh, P  Dar, MS  Dar, MJ 
Citation: Singh P, etal., FEBS Lett. 2016 Aug 23. doi: 10.1002/1873-3468.12377.
RGD ID: 11535140
Pubmed: PMID:27552098   (View Abstract at PubMed)
DOI: DOI:10.1002/1873-3468.12377   (Journal Full-text)

Class-1 phosphatidylinositol-3-kinases (PI3Ks) are activated by a variety of extracellular stimuli and have been implicated in a wide range of cellular processes. p110alpha and p110beta are the two most studied isoforms of the class-1A PI3K signaling pathway. Although these two isoforms are ubiquitously expressed and play multiple redundant roles, they also have distinct functions within the cell. More recently, p110alpha and p110beta isoforms have been shown to translocate into the nucleus and play a role in DNA replication and repair, and in cell cycle progression. In the following Review article, we discuss the overlapping and unique roles of p110alpha and p110beta isoforms with a particular focus on their structure, expression analysis, subcellular localization, and signaling contributions in various cell types and model organisms.


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