RGD Reference Report - miR-193a-3p is a potential tumor suppressor in malignant pleural mesothelioma. - Rat Genome Database

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miR-193a-3p is a potential tumor suppressor in malignant pleural mesothelioma.

Authors: Williams, M  Kirschner, MB  Cheng, YY  Hanh, J  Weiss, J  Mugridge, N  Wright, CM  Linton, A  Kao, SC  Edelman, JJ  Vallely, MP  McCaughan, BC  Cooper, W  Klebe, S  Lin, RC  Brahmbhatt, H  MacDiarmid, J  Van Zandwijk, N  Reid, G 
Citation: Williams M, etal., Oncotarget. 2015 Sep 15;6(27):23480-95.
RGD ID: 11529530
Pubmed: PMID:26125439   (View Abstract at PubMed)
PMCID: PMC4695131   (View Article at PubMed Central)
DOI: DOI:10.18632/oncotarget.4346   (Journal Full-text)

Malignant pleural mesothelioma (MPM) is an asbestos-induced cancer with poor prognosis that displays characteristic alterations in microRNA expression. Recently it was reported that the expression of a subset of microRNAs can distinguish between MPM and adenocarcinoma of the lung. However, the functional importance of these changes has yet to be investigated. We compared expression of miR-192, miR-193a-3p and the miR-200 family in normal pleura and MPM tumor specimens and found a statistically significant reduction in the levels of miR-193a-3p (3.1-fold) and miR-192 (2.8-fold) in MPM. Transfection of MPM cells with a miR-193a-3p mimic resulted in inhibition of growth and an induction of apoptosis and necrosis in vitro. The growth inhibitory effects of miR-193a-3p were associated with a decrease in MCL1 expression and were recapitulated by RNAi-mediated MCL1 silencing. Targeted delivery of miR-193a-3p mimic using EDV minicells inhibited MPM xenograft tumour growth, and was associated with increased apoptosis. In conclusion, miR-193a-3p appears to have importance in the biology of MPM and may represent a target for therapeutic intervention.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
malignant pleural mesothelioma  IEP 11529530; 11529530; 11529530miRNA:decreased expression:pleura (human)RGD 
malignant pleural mesothelioma  ISOMIR192 (Homo sapiens)11529530; 11529530miRNA:decreased expression:pleura (human)RGD 
malignant pleural mesothelioma  ISOMIR193A (Homo sapiens)11529530; 11529530miRNA:decreased expression:pleura (human)RGD 
malignant pleural mesothelioma  ISOMIR200B (Homo sapiens)11529530; 11529530miRNA:decreased expression:pleura (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Mir192  (microRNA 192)
Mir193a  (microRNA 193a)
Mir200b  (microRNA 200b)

Genes (Mus musculus)
Mir192  (microRNA 192)
Mir193a  (microRNA 193a)
Mir200b  (microRNA 200b)

Genes (Homo sapiens)
MIR192  (microRNA 192)
MIR193A  (microRNA 193a)
MIR200B  (microRNA 200b)


Additional Information