RGD Reference Report - The expression and concentration of CD40 ligand in normal pregnancy, preeclampsia, and hemolytic anemia, elevated liver enzymes and low platelet count (HELLP) syndrome. - Rat Genome Database
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The expression and concentration of CD40 ligand in normal pregnancy, preeclampsia, and hemolytic anemia, elevated liver enzymes and low platelet count (HELLP) syndrome.

Authors: Azzam, HA  Abousamra, NK  Goda, H  El-Shouky, R  El-Gilany, AH 
Citation: Azzam HA, etal., Blood Coagul Fibrinolysis. 2013 Jan;24(1):71-5. doi: 10.1097/MBC.0b013e32835a8aca.
RGD ID: 11522719
Pubmed: (View Article at PubMed) PMID:23241952
DOI: Full-text: DOI:10.1097/MBC.0b013e32835a8aca

Preeclampsia has been associated with increased platelet activation detected before disease onset. Inappropriate activation of platelets may be involved in pathogenesis in preeclampsia by promoting coagulation and thrombosis and also as a mediator of inflammation. The exaggerated platelet activation and inflammation leading to endothelial damage in preeclampsia can be explained by the CD40-CD40 ligand (CD40L) system. Expression of CD40L on platelets was determined by whole-blood flow cytometry, and serum levels of soluble CD40L (sCD40L) were measured by enzyme-linked immunosorbent assay in 11 women with mild preeclampsia, 11 women with severe preeclampsia, and six women with hemolytic anemia, elevated liver enzymes and low platelet count (HELLP) syndrome compared with 13 normotensive pregnant women as a control group. The platelet surface expression of CD40L was significantly higher in women with mild and severe preeclampsia and HELLP compared with normal pregnancy group (P = 0.001; P

Annotation

Disease Annotations    
HELLP syndrome  (IEP,ISO)
pre-eclampsia  (IEP,ISO)

Objects Annotated

Genes (Rattus norvegicus)
Cd40lg  (CD40 ligand)

Genes (Mus musculus)
Cd40lg  (CD40 ligand)

Genes (Homo sapiens)
CD40LG  (CD40 ligand)


Additional Information