RGD Reference Report - CD40/CD40 ligand signaling in mouse cerebral microvasculature after focal ischemia/reperfusion. - Rat Genome Database

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CD40/CD40 ligand signaling in mouse cerebral microvasculature after focal ischemia/reperfusion.

Authors: Ishikawa, M  Vowinkel, T  Stokes, KY  Arumugam, TV  Yilmaz, G  Nanda, A  Granger, DN 
Citation: Ishikawa M, etal., Circulation. 2005 Apr 5;111(13):1690-6. Epub 2005 Mar 28.
RGD ID: 11352234
Pubmed: PMID:15795333   (View Abstract at PubMed)
DOI: DOI:10.1161/01.CIR.0000160349.42665.0C   (Journal Full-text)

BACKGROUND: CD40/CD40 ligand (CD40L) signaling contributes to proinflammatory and prothrombogenic responses in the vasculature. CD40/CD40L expression is elevated in patients after a transient ischemic attack or stroke. The purpose of this study was to investigate the role of CD40/CD40L signaling in cerebral microvascular dysfunction and tissue injury response to middle cerebral artery occlusion (MCAO) and reperfusion. METHODS AND RESULTS: Intravital fluorescence microscopy was used to visualize the cerebral microcirculation of wild-type (WT), CD40-deficient, and CD40L-deficient mice subjected to 1-hour MCAO and 4-hour reperfusion. The adhesion of platelets and of leukocytes and vascular permeability were measured in postcapillary venules after 4-hour and 1-hour reperfusions, respectively. Cerebral infarct volume was analyzed 24 hours after reperfusion. Platelet and leukocyte adhesion was elevated and blood/brain barrier function was compromised by MCAO in WT mice. Blood cell recruitment and increased permeability were blunted in both CD40-deficient and CD40L-deficient mice. Infarct volume was also reduced in CD40- and CD40L-deficient mice compared with WT mice. CONCLUSIONS: Our findings indicate that CD40/CD40L signaling contributes to inflammatory and prothrombogenic responses and brain infarction induced by MCAO and reperfusion. The CD40/CD40L dyad may play a significant pathogenic role in the acute phase of ischemic stroke.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
transient cerebral ischemia severityISOCd40 (Mus musculus)11352234; 11352234 RGD 
transient cerebral ischemia severityISOCd40lg (Mus musculus)11352234; 11352234 RGD 
transient cerebral ischemia severityIMP 11352234; 11352234 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Cd40  (CD40 molecule)
Cd40lg  (CD40 ligand)

Genes (Mus musculus)
Cd40  (CD40 antigen)
Cd40lg  (CD40 ligand)

Genes (Homo sapiens)
CD40  (CD40 molecule)
CD40LG  (CD40 ligand)


Additional Information