RGD Reference Report - Decreased expression of both Fc gamma RII and Fc gamma RIII mRNA in leukemic granulocytes. - Rat Genome Database

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Decreased expression of both Fc gamma RII and Fc gamma RIII mRNA in leukemic granulocytes.

Authors: Kant, A  Advani, S  Zingde, S 
Citation: Kant A, etal., Leuk Res. 1995 Dec;19(12):997-1000.
RGD ID: 11344957
Pubmed: PMID:8632671   (View Abstract at PubMed)

Morphologically mature granulocytes from patients with chronic myeloid leukemia exhibit a defect in internalization of heat-aggregated IgG. In this study, we investigate the status of the steady-state levels of the mRNA for the two receptors for IgG, Fc gamma RII and Fc gamma RIII, as a step towards understanding the molecular basis of the defect and in turn the discordant maturation of the leukemic cells. Our data show that the mRNA for both receptors is lower in the leukemic cells relative to the normal cells. This may be one of the causes for the defective endocytosis.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
FCGR2AHumanchronic myeloid leukemia  IEP  RGD 
Fcgr2aRatchronic myeloid leukemia  ISOFCGR2A (Homo sapiens) RGD 
Fcgr3Mousechronic myeloid leukemia  ISOFCGR2A (Homo sapiens) RGD 

Objects Annotated

Genes (Rattus norvegicus)
Fcgr2a  (Fc gamma receptor 2A)

Genes (Mus musculus)
Fcgr3  (Fc receptor, IgG, low affinity III)

Genes (Homo sapiens)
FCGR2A  (Fc gamma receptor IIa)


Additional Information