RGD Reference Report - miR-152 functions as a tumor suppressor in colorectal cancer by targeting PIK3R3. - Rat Genome Database

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miR-152 functions as a tumor suppressor in colorectal cancer by targeting PIK3R3.

Authors: Li, B  Xie, Z  Li, B 
Citation: Li B, etal., Tumour Biol. 2016 Jan 28.
RGD ID: 11341114
Pubmed: PMID:26820128   (View Abstract at PubMed)
DOI: DOI:10.1007/s13277-016-4888-2   (Journal Full-text)

Accumulating evidence showed that microRNA-152 (miR-152) was frequently downregulated, and functioned as tumor suppressor in many cancers, but little is known about its biological role and intrinsic regulatory mechanisms in colorectal cancer (CRC). Here, we explored the potential role of miR-152 in CRC and the possible molecular mechanisms. Our results proved that miR-152 expression was downregulated in CRC cell lines and tissue samples, and its expression was inversely correlated with advanced tumor-node-metastasis (TNM) stage (P < 0.01) and lymph node metastasis (P < 0.01). Function assays demonstrated that restoring the expression of miR-152 in CRC cells dramatically reduced the cell proliferation and cell migration and invasion and promoted apoptosis and caspase-3 activity in vitro, as well as suppressed tumor growth in vivo. Mechanistic investigations defined phosphoinositide-3-kinase regulatory subunit 3 (PIK3R3) as a direct and functional downstream target of miR-152. In addition, we also found that PIK3R3 expression was upregulated and was inversely correlated with miR-152 expression in clinical CRC tissues. Downregulation of PIK3R3 mimicked the tumor-suppressive effects of miR-152 overexpression in CRC cells. Taken together, these results elucidated the function of miR-152 in CRC progression and suggested that miR-152 might function as tumor suppressor in CRC by targeting PIK3R3.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
colorectal cancer disease_progressionIEP 11341114miRNA:decreased expression:colorectumRGD 
colorectal cancer treatmentIDA 11341114 RGD 
colorectal cancer disease_progressionISOMIR152 (Homo sapiens)11341114; 11341114miRNA:decreased expression:colorectumRGD 
colorectal cancer treatmentISOMIR152 (Homo sapiens)11341114; 11341114 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Mir152  (microRNA 152)

Genes (Mus musculus)
Mir152  (microRNA 152)

Genes (Homo sapiens)
MIR152  (microRNA 152)


Additional Information