RGD Reference Report - Binding of CXCL8/IL-8 to Mycobacterium tuberculosis Modulates the Innate Immune Response. - Rat Genome Database

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Binding of CXCL8/IL-8 to Mycobacterium tuberculosis Modulates the Innate Immune Response.

Authors: Krupa, A  Fol, M  Dziadek, BR  Kepka, E  Wojciechowska, D  Brzostek, A  Torzewska, A  Dziadek, J  Baughman, RP  Griffith, D  Kurdowska, AK 
Citation: Krupa A, etal., Mediators Inflamm. 2015;2015:124762. doi: 10.1155/2015/124762. Epub 2015 Aug 2.
RGD ID: 11250849
Pubmed: PMID:26300588   (View Abstract at PubMed)
PMCID: PMC4537748   (View Article at PubMed Central)
DOI: DOI:10.1155/2015/124762   (Journal Full-text)

Interleukin-8 (IL-8) has been implicated in the pathogenesis of several human respiratory diseases, including tuberculosis (TB). Importantly and in direct relevance to the objectives of this report quite a few findings suggest that the presence of IL-8 may be beneficial for the host. IL-8 may aid with mounting an adequate response during infection with Mycobacterium tuberculosis (M. tb); however, the underlying mechanism remains largely unknown. The major goal of our study was to investigate the contribution of IL-8 to the inflammatory processes that are typically elicited in patients with TB. We have shown for the first time that IL-8 can directly bind to tubercle bacilli. We have also demonstrated that association of IL-8 with M. tb molecules leads to the augmentation of the ability of leukocytes (neutrophils and macrophages) to phagocyte and kill these bacilli. In addition, we have shown that significant amount of IL-8 present in the blood of TB patients associates with erythrocytes. Finally, we have noted that IL-8 is the major chemokine responsible for recruiting T lymphocytes (CD3(+), CD4(+), and CD8(+) T cells). In summary, our data suggest that the association of IL-8 with M. tb molecules may modify and possibly enhance the innate immune response in patients with TB.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Mycobacterium avium complex disease  IEP 11250849protein:increased expression:blood plasma and erythrocyte (human)RGD 
Mycobacterium avium complex disease  ISOCXCL8 (Homo sapiens)11250849protein:increased expression:blood plasma and erythrocyte (human)RGD 
tuberculosis  IEP 11250849protein:increased expression:blood plasma and erythrocyte (human)RGD 
tuberculosis  ISOCXCL8 (Homo sapiens)11250849protein:increased expression:blood plasma and erythrocyte (human)RGD 

Objects Annotated

Genes (Mus musculus)
Cxcl15  (C-X-C motif chemokine ligand 15)

Genes (Homo sapiens)
CXCL8  (C-X-C motif chemokine ligand 8)


Additional Information