RGD Reference Report - Correlation of Fc(gamma)RIIa (CD32) Polymorphism and IgG Antibody Subclasses in Hemolytic Disease of Newborn. - Rat Genome Database

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Correlation of Fc(gamma)RIIa (CD32) Polymorphism and IgG Antibody Subclasses in Hemolytic Disease of Newborn.

Authors: Wu, Q  Zhang, Y  Liu, M  Wang, B  Liu, S  He, C 
Citation: Wu Q, etal., Neonatology. 2009;96(1):1-5. doi: 10.1159/000189239. Epub 2009 Jan 8.
RGD ID: 11100009
Pubmed: PMID:19129718   (View Abstract at PubMed)
DOI: DOI:10.1159/000189239   (Journal Full-text)

ABO-HDN is a common disease of newborn in China and currently there is no satisfactory method to predict it in the antepartum period. It has been reported that Fc(gamma)RIIa (CD32) genotype is associated with both infectious diseases induced by bacteria and parasitemia. There is a relationship between IgG subclass and RH-HDN. To study the pathogenesis of ABO-HDN and to find reliable method to diagnose ABO-HDN, we investigated the polymorphism of Fc(gamma)RIIa (CD32) and distribution of IgG subclass in infants with ABO-HDN and their mothers by polymerase chain reaction or ELISA assay. We observed that the frequency of HH131 genotype is lower in infants with ABO-HDN than in controls (p < 0.01), while the frequency of HR131 genotype is higher in ABO-HDN infants than that in controls (p < 0.01). The genotype HR131 and concentrations of IgG1 and IgG3 are significantly correlated with ABO-HDN. Our results demonstrated, for the first time, that there is a correlation between ABO-HDN and CD32, and different IgG subclass distribution. Our study may contribute to the development of an early diagnostic method for HDN.

RGD Manual Disease Annotations    Click to see Annotation Detail View

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
FCGR2AHumanhemolytic disease of the fetus  IAGP DNA:polymorphism: :RGD 
Fcgr2aRathemolytic disease of the fetus  ISOFCGR2A (Homo sapiens)DNA:polymorphism: :RGD 
Fcgr3Mousehemolytic disease of the fetus  ISOFCGR2A (Homo sapiens)DNA:polymorphism: :RGD 

Objects Annotated

Genes (Rattus norvegicus)
Fcgr2a  (Fc gamma receptor 2A)

Genes (Mus musculus)
Fcgr3  (Fc receptor, IgG, low affinity III)

Genes (Homo sapiens)
FCGR2A  (Fc gamma receptor IIa)

Additional Information