RGD Reference Report - Mucosal cytokine profiles in paediatric eosinophilic oesophagitis: a case-control study. - Rat Genome Database

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Mucosal cytokine profiles in paediatric eosinophilic oesophagitis: a case-control study.

Authors: Romano, C  Chiaro, A  Lucarelli, S  Santarelli, C  Cucchiara, S  Guadagnini, T  Miele, E  Di Nardo, G 
Citation: Romano C, etal., Dig Liver Dis. 2014 Jul;46(7):590-5. doi: 10.1016/j.dld.2014.03.003. Epub 2014 Apr 3.
RGD ID: 11081157
Pubmed: PMID:24704289   (View Abstract at PubMed)
DOI: DOI:10.1016/j.dld.2014.03.003   (Journal Full-text)

BACKGROUND: Eosinophilic oesophagitis is an inflammatory condition characterized by a dense eosinophilic infiltrate. The migration of eosinophils into the oesophagus is influenced by cytokines such as IL-5, IL-13 and eotaxin-3. The aim of this study was to evaluate changes in the cytokine expression profiles (IL-5, IL-13 and eotaxin-3/CCL26) in children after topical steroid treatment. METHODS: a prospective case-control study was performed in 23 paediatric patients (age 5-16 years) with a histological diagnosis of eosinophilic oesophagitis. Histological evaluation and cytokine levels assay (IL-5, IL-13 and eotaxin-3/CCL26) in the proximal and distal oesophagus were performed before, and after 8 weeks of topical budesonide. Data were compared with a matched healthy control group. RESULTS: quantitative expression levels of IL-5, IL-13 and eotaxin-3 were significantly higher in the eosinophilic oesophagitis group both compared to healthy subjects (p<0.0001). A significant reduction of the eosinophil infiltrate as well as of IL-5, IL-13 and eotaxin-3 mucosal profiles was observed after steroid treatment both at the proximal and distal oesophagus (p<0.0001). CONCLUSIONS: IL-5, IL-13 and eotaxin-3/CCL26 are significantly over-expressed in the oesophageal epithelium of children with eosinophilic oesophagitis. Topical steroid treatment (inhaled and swallowed budesonide) can induce clinical response with partial mucosal remission.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
CCL26Humaneosinophilic esophagitis  IEP protein:increased expression:esophagus (human)RGD 
Ccl26Rateosinophilic esophagitis  ISOCCL26 (Homo sapiens)protein:increased expression:esophagus (human)RGD 
Ccl26Mouseeosinophilic esophagitis  ISOCCL26 (Homo sapiens)protein:increased expression:esophagus (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ccl26  (C-C motif chemokine ligand 26)

Genes (Mus musculus)
Ccl26  (C-C motif chemokine ligand 26)

Genes (Homo sapiens)
CCL26  (C-C motif chemokine ligand 26)


Additional Information