RGD Reference Report - Kynurenine-3-monooxygenase: a review of structure, mechanism, and inhibitors. - Rat Genome Database

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Kynurenine-3-monooxygenase: a review of structure, mechanism, and inhibitors.

Authors: Smith, JR  Jamie, JF  Guillemin, GJ 
Citation: Smith JR, etal., Drug Discov Today. 2016 Feb;21(2):315-24. doi: 10.1016/j.drudis.2015.11.001. Epub 2015 Nov 14.
RGD ID: 11081069
Pubmed: PMID:26589832   (View Abstract at PubMed)
DOI: DOI:10.1016/j.drudis.2015.11.001   (Journal Full-text)

Kynurenine monooxygenase (KMO) is an enzyme of the kynurenine (Kyn) pathway (KP), which is the major catabolic route of tryptophan. Kyn represents a branch point of the KP, being converted into the neurotoxin 3-hydroxykynurenine via KMO, neuroprotectant kynurenic acid, and anthranilic acid. As a result of this branch point, KMO is an attractive drug target for several neurodegenerative and/or neuroinflammatory diseases, especially Huntington's (HD), Alzheimer's (AD), and Parkinson's (PD) diseases. Although a neurological target, administration of KMO inhibitors in the periphery has demonstrated promising pharmacological results. In light of a recent crystal structure release and reports of preclinical candidates, here we provide a concise yet comprehensive update on the current state of research into the enzymology of KMO and related drug discovery efforts, highlighting areas where further work is required.

Molecular Pathway Annotations    Click to see Annotation Detail View

RGD Manual Annotations

TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
kynurenine metabolic pathway   TAS 11081069 RGD 
kynurenine metabolic pathway   ISOKMO (Homo sapiens)11081069; 11081069 RGD 
Objects Annotated

Genes (Rattus norvegicus)
Kmo  (kynurenine 3-monooxygenase)

Genes (Mus musculus)
Kmo  (kynurenine 3-monooxygenase)

Genes (Homo sapiens)
KMO  (kynurenine 3-monooxygenase)


Additional Information