RGD Reference Report - Intestinal infection with Trichinella spiralis induces distinct, regional immune responses. - Rat Genome Database

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Intestinal infection with Trichinella spiralis induces distinct, regional immune responses.

Authors: Blum, LK  Mohanan, S  Fabre, MV  Yafawi, RE  Appleton, JA 
Citation: Blum LK, etal., Vet Parasitol. 2013 May 20;194(2-4):101-5. doi: 10.1016/j.vetpar.2013.01.030. Epub 2013 Feb 5.
RGD ID: 11049476
Pubmed: PMID:23465441   (View Abstract at PubMed)
PMCID: PMC3655129   (View Article at PubMed Central)
DOI: DOI:10.1016/j.vetpar.2013.01.030   (Journal Full-text)

The aim of this study was to evaluate differences between the small and large intestines (SI and LI) with regard to colonization and immunity during infection with Trichinella spiralis. In orally infected C57BL/6 mice, the gender ratios of worms differed among the SI, cecum, and LI. Mucosal mastocytosis developed in the SI but not in the LI, consistent with reduced IL-9 and IL-13 production by explants from the LI. Despite these differences, worms were cleared at the same rate from both sites. Furthermore, IL-10 production was reduced in the LI, yet it was instrumental in limiting local inflammation. Finally, passive immunization of rat pups with tyvelose-specific antibodies effectively cleared fist-stage larvae from all intestinal regions. We conclude that despite regional differences in immune responsiveness and colonization, immune mechanisms that clear T. spiralis operate effectively throughout the intestinal tract.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
IL10Humantrichinosis  ISOIl10 (Mus musculus) RGD 
Il10Rattrichinosis  ISOIl10 (Mus musculus) RGD 
Il10Mousetrichinosis  IMP  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Il10  (interleukin 10)

Genes (Mus musculus)
Il10  (interleukin 10)

Genes (Homo sapiens)
IL10  (interleukin 10)


Additional Information