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Common genetic variants in candidate genes and risk of familial lymphoid malignancies.

Authors: Liang, XS  Caporaso, N  McMaster, ML  Ng, D  Landgren, O  Yeager, M  Chanock, S  Goldin, LR 
Citation: Liang XS, etal., Br J Haematol. 2009 Aug;146(4):418-23. doi: 10.1111/j.1365-2141.2009.07790.x. Epub 2009 Jul 1.
Pubmed: (View Article at PubMed) PMID:19573080
DOI: Full-text: DOI:10.1111/j.1365-2141.2009.07790.x

Familial aggregation, linkage and case-control studies support the role of germline genes in the aetiology of lymphoid malignancies. To further examine the role of genetic variation underlying susceptibility, we analysed 1536 single nucleotide polymorphisms in 152 genes involved in apoptosis, DNA repair, immune response and oxidative stress pathways among a unique sample of 165 unrelated familial cases including patients with chronic lymphocytic leukaemia (CLL), Waldenstrom macroglobulinaemia (WM) and Hodgkin lymphoma (HL), and 107 spouse controls. We confirmed previous studies showing a polymorphism in the IL10 promoter (rs1800890/-3575T>A) to be associated with non-Hodgkin lymphoma, as this allele was found to be associated with both CLL and WM. We also confirmed the role of IL6 variation to be associated with HL. Polymorphisms in TNFSF10 were associated with both CLL and WM. Future replication and functional studies are needed to clarify the role of these genetic variants. Finally, our data further support the close association of WM and CLL.

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RGD Object Information
RGD ID: 11049165
Created: 2016-04-05
Species: All species
Last Modified: 2016-04-05
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.