RGD Reference Report - Submicroscopic infections with Plasmodium falciparum during pregnancy and their association with circulating cytokine, chemokine, and cellular profiles. - Rat Genome Database

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Submicroscopic infections with Plasmodium falciparum during pregnancy and their association with circulating cytokine, chemokine, and cellular profiles.

Authors: Ibitokou, SA  Bostrom, S  Brutus, L  Tuikue Ndam, N  Vianou, B  Agbowai, C  Amadoudji Zin, M  Huynh, BT  Massougbodji, A  Deloron, P  Troye-Blomberg, M  Fievet, N  Luty, AJ 
Citation: Ibitokou SA, etal., Clin Vaccine Immunol. 2014 Jun;21(6):859-66. doi: 10.1128/CVI.00009-14. Epub 2014 Apr 9.
RGD ID: 11041890
Pubmed: PMID:24717969   (View Abstract at PubMed)
PMCID: PMC4054237   (View Article at PubMed Central)
DOI: DOI:10.1128/CVI.00009-14   (Journal Full-text)

The immunological consequences of pregnancy-associated malaria (PAM) due to Plasmodium falciparum have been extensively investigated in cross-sectional studies conducted at delivery, but there have been very few longitudinal studies of changes due to PAM during pregnancy. We conducted a prospective study in Benin to investigate the changes associated with PAM in groups of 131 and 111 women at inclusion in the second trimester and at delivery, respectively. Infected women were identified by standard microscopic examinations of blood smears and by quantitative PCR (qPCR) assays and were matched to uninfected control women by age, gestational age, and gravidity. We quantified plasma levels of a panel of soluble immunological mediators and other mediators, as well as the frequencies of peripheral blood mononuclear cell types. Comparisons of these variables in infected and uninfected women used multivariate analyses, and we also assessed the predictive value of variables measured at inclusion for pregnancy outcomes at delivery. In multivariate analyses, peripheral plasma interleukin 10 (IL-10) and gamma interferon-inducible protein 10 (IP-10) levels were associated with PAM at inclusion and at delivery, while higher IL-10 levels distinguished qPCR-detectable submicroscopic infections at inclusion but not at delivery. Maternal anemia at delivery was associated with markers of proinflammatory (increased frequency of monocytes) and anti-inflammatory (increased IL-10 levels and increased activation of regulatory T cells) activity measured at inclusion. Elevated concentrations of IL-10 are associated with the majority of P. falciparum infections during pregnancy, but this marker alone does not identify all submicroscopic infections. Reliably identifying such occult infections will require more sensitive and specific methods.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Pregnancy-associated Malaria  IEP 11041890 RGD 
Pregnancy-associated Malaria  ISOIL10 (Homo sapiens)11041890; 11041890 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Il10  (interleukin 10)

Genes (Mus musculus)
Il10  (interleukin 10)

Genes (Homo sapiens)
IL10  (interleukin 10)


Additional Information