RGD Reference Report - Evidence of a U-shaped association between factor XII activity and overall survival. - Rat Genome Database

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Evidence of a U-shaped association between factor XII activity and overall survival.

Authors: Endler, G  Marsik, C  Jilma, B  Schickbauer, T  Quehenberger, P  Mannhalter, C 
Citation: Endler G, etal., J Thromb Haemost. 2007 Jun;5(6):1143-8.
RGD ID: 11041782
Pubmed: PMID:17388965   (View Abstract at PubMed)
DOI: DOI:10.1111/j.1538-7836.2007.02530.x   (Journal Full-text)

INTRODUCTION: The clinical relevance of decreased coagulation factor XII (FXII) plasma activity as a risk factor for both venous and arterial thrombosis is still discussed controversially. The current study evaluated the predictive value of FXII levels for all-cause mortality in a large Viennese patient cohort. PATIENTS AND METHODS: Individuals, whose FXII activity levels were determined for suspected coagulation disorders or thrombophilia screening between 1991-2003 were included in this study (n = 8936, 51% male, 49% female, median age 43 years). Death/survival was determined by record linkage with the Austrian Death Registry. The median observation period was 5 years covering a total of 46 400 person years; the death rate was 17.1%. For Cox regression analysis, FXII plasma activity was divided into 11 categories of 10% steps with the category of > 100% FXII serving as a reference category. RESULTS: With decreasing FXII plasma activity, hazard ratios for all-cause mortality gradually increased linearly from 1.0 in the > 100% category to 1.5 (95% CI: 1.2-1.9) in the 80-90% category to 4.7 (95% CI: 3.4-6.5) in the 10-20% category. Similar results were obtained, when only vascular mortality or death as a result of ischemic heart disease was considered. No significant increase in all-cause mortality (HR: 1.4, 95%CI 0.7-2.8) was observed in the small group of FXII-deficient subjects [0-10% category (n = 58)]. CONCLUSIONS: This study first demonstrates a strong and almost linear association of FXII plasma activity between 90% and 10% with all-cause mortality in a large Viennese patient cohort. Interestingly, mortality rates are not increased when FXII activity is below 10%, resulting in a U-shaped survival curve.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Death  IEP 11041782 RGD 
Death  ISOF12 (Homo sapiens)11041782; 11041782 RGD 

Objects Annotated

Genes (Rattus norvegicus)
F12  (coagulation factor XII)

Genes (Mus musculus)
F12  (coagulation factor XII (Hageman factor))

Genes (Homo sapiens)
F12  (coagulation factor XII)


Additional Information